PREDICTION OF THE EFFICIENCY OF SURGICAL TREATMENT FOR INFERTILITY IN WOMEN WITH MINOR FORMS OF EXTERNAL GENITAL ENDOMETRIOSIS
- Authors: KRASILNIKOVA A.K1, MALYSHKINA A.I1, SOTNIKOVA N.Y.1, ANTSIFEROVA Y.S1
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Affiliations:
- V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation
- Issue: No 7 (2013)
- Pages: 36-39
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247000
- ID: 247000
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Open Access
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Abstract
Objective. To assess whether the immunological parameters associated with the activity of humoral immune reactions may be used to predict the efficiency of surgical treatment for infertility in women with minor forms of external genital endometriosis. Subject and methods. Peripheral blood was examined in 33 women with infertility caused by minor forms of external genital endometriosis (a study group) and 19 healthy fertile women (a control group). The levels of B, B1 cells, Th2 lymphocytes and the serum content of IL-4 and IL-6 were determined. Results. In the study group women, the peripheral blood showed increases in the content of B1 lymphocytes and Th2 cells and the serum level of IL-4 and IL-6. The maximum magnitude of immune disorders was associated with the absence of pregnancy after laparoscopy. Conclusion. The level of B1 lymphocytes enables one to predict the efficiency of surgical treatment for infertility in women with minor forms of external endometriosis.
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About the authors
A. K KRASILNIKOVA
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation
Email: ivniimid@ivnet.ru
A. I MALYSHKINA
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation
Email: ivniimid@ivnet.ru
N. YU SOTNIKOVA
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation
Email: niimid.immune@mail.ru
YU. S ANTSIFEROVA
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of the Russian Federation
Email: niimid.immune@mail.ru
References
- Holoch K.J., Lessey B.A. Endometriosis and infertility. Clin Obstet Gynecol. 2010;53(2):429—438.
- Ozkan S., Murk W., Arici A. Endometriosis and infertility: epidemiology and evidence-based treatments Ann N Y Acad Sci. 2008;1127:92—100.
- Адамян Л.В., Андреева Е.Н. Роль современной гормонмодулирующей терапии в комплексном лечении генитального эндометриоза. Проблемы репродукции. 2011; 17(6): 66—77.
- Budinetz T., Sanfilippo J. S. Treatment of endometriosis: a hormonal approach Minerva Ginecol. 2010;62(4):373—380.
- Ge C.X., Zhu X.H., Tang X.Q. Efficacy of conservative laparoscopic surgery combined with goserelin in treatment of 206 patients with severe ovarian endometriosis at short-term and long-term follow-up. Zhonghua Fu Chan Ke Za Zhi. 2012;47(8):603—607.
- Catenacci M., Sastry S., Falcone T. Laparoscopic surgery for endometriosis. Clin Obstet Gynecol. 2009;52(3): 351—361.
- Diwadkar G.B., Falcone T. Surgical management of pain and infertility secondary to endometriosis. Semin Reprod Med. 2011;29(2):124—129.
- Chen M.L., Lee K.C., Yang C.T., Hung K.H., Wu M.H. Simultaneous laparoscopy for endometriotic women undergoing in vitro fertilization. Taiwan J Obstet Gynecol. 2012;51(1):66—70.
- Jacobson T.Z., Duffy J.M., Barlow D., Farquhar C., Koninckx P.R., Olive D. Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev. 2010;(1):CD001398.
- Bianco B., André G.M., Vilarino F.L., Peluso C., Mafra F.A., Christofolini D.M. et al. The possible role of genetic variants in autoimmune-related genes in the development of endometriosis. Hum Immunol. 2012;73(3):306—315.
- Gajbhiye R., Suryawanshi A., Khan S., Meherji P., Warty N. et al. Multiple endometrial antigens are targeted in autoimmune endometriosis. Reprod Biomed Online. 2008;16(6): 817—824.
- Nabeta M., Abe Y., Kagawa L., Haraguchi R., Kito K., Ueda N. et al. Identification of anti-a-enolase autoantibody as a novel serum marker for endometriosis. Proteomics Clin Appl. 2009; 3(10):1201—1210.
- Inagaki J., Hao L., Nakatsuka M., Yasuda T., Hiramatsu Y., Shoenfeld Y. et al. A possible mechanism of autoimmune-mediated infertility in women with endometriosis. Am J Reprod Immunol. 2011; 66(2):90—99.
- Duan B., Morel L. Role of B-1a cells in autoimmunity. Autoimmun Rev. 2006; 5(6):403—408.
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