CLINICAL AND MOLECULAR GENETIC PREDICTORS FOR CONGENITAL INFECTION IN NEONATAL INFANTS WITH INTRAUTERINE GROWTH RETARDATION
- Authors: LOMOVA N.A1, KAN N.E1, DONNIKOV A.E1, ZUBKOV V.V1, TYUTYUNNIK V.L1, SUKHIKH G.T1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Issue: No 8 (2013)
- Pages: 35-39
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247002
- ID: 247002
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Abstract
According to the current ideas, congenital infection occurring in babies during the first days of life is a common complication in newborn infants with intrauterine growth retardation (IUGR) in early neonatality. Objective. To study the role of cytokine gene polymorphisms in the occurrence of congenital infection in pregnant women with growth retardation of a fetus and their neonatal infants. Subject and methods. Two hundred and ten mother-infant pairs underwent a prospective examination, by investigating the distribution of alleles and genotypes of cytokine gene polymorphic loci in the mothers and their newborn infants. Results. The risk factors of intrauterine infection in patients with placental insuff iciency should include chronic urinary tract diseases (chronic pyelonephritis and cystitis); a history of spontaneous abortions; isthmicocervical insufficiency and polyhydramnios during the current pregnancy. The presence of an A/A genotype of IL-10 gene polymorphism: -592 A>C in a baby is associated with the increased probability of intrauterine infection in placental insufficiency, the clinical manifestation of which is fetal growth retardation (FGR) and chronic fetal hypoxia (p = 0.031; OR = 18.9(1.7-215.2)). Conclusion. The findings allow the determination of IL-10 gene polymorphism in newborn infants with IUGR to be used as a predictor of congenital infection.
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About the authors
N. A LOMOVA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: n_lomova@oparina4.ru
Moscow
N. E KAN
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: n_kan@oparina4.ru
Moscow
A. E DONNIKOV
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: a_donnikov@oparina4.ru
Moscow
V. V ZUBKOV
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: v_zubkov@oparina4.ru
Moscow
V. L TYUTYUNNIK
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: v_tioutiounnik@oparina4.ru
Moscow
G. T SUKHIKH
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: g_sukhih@oparina4.ru
Moscow
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