ENDOMETRIAL MORPHOLOGICAL AND MOLECULAR BIOLOGICAL FEATURES DURING THE IMPLANTATION WINDOW IN PATIENTS WITH INFERTILITY CONCURRENT WITH STAGES 1-2 EXTERNAL GENITAL ENDOMETRIOSIS
- Authors: KOGAN E.A1, KOLOTOVKINA A.V1, FAIZULLINA N.M1, KALININA E.A1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Issue: No 9 (2013)
- Pages: 35-40
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247020
- ID: 247020
Cite item
Abstract
Objective. To study endometrial morphological and molecular biological features in patients with infertility and Stage 1—2 external genital endometriosis (EGE) during the implantation window. Subject and methods. Seventy-two infertile patients, including 23 with Stage 1-2 EGE and 32 with tuboperitoneal factor (TPF) infertility, and 17 with male factor (MF) infertility were examined. All the patients underwent pipelle (aspiration) endometrial biopsy at 6-8 weeks after ovulation, followed by histological and immunohistochemical examinations. The number of pinopodia, the expression of estrogen receptor-α (ER-α) and progesterone receptor A (PR-A) in the endometrial stroma and epithelium, as well as stromal PR/ER-а ratio were determined. Results and discussion. The patents with Stage 1-2 EGE were found to have a significant increase in the expression of ER-α in both the endometrial stroma and epithelium (p=0.031 and p=0.027). In all the groups, the endometrial stromal and epithelial level of PR-A was decreased in relation to the phase of endometrial development (p = 0.013; p = 0.032); but was statistically indifferent between the groups (p=0.186; p=0.503). The mean number of pinopodia in the endometrium of the patients with Stage 1-2 EGE and TPF was significantly lower than in those with MF (p = 0.02). Conclusion. The findings suggest that in patients with infertility concurrent with Stage 1-2 EGE, impaired endometrial receptivity occurs during the implantation window which manifests itself as lower pinopodium count and impaired hormone receptor balance. The significantly higher epithelial and stromal ER-α levels are the peculiarity of endometrial changes during the implantation window in Stage 1-2 EGE. This, in turn, may be one of the leading causes of infertility and the lower efficiency of an LVF program in patients with this disease.
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About the authors
E. A KOGAN
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: e_kogan@oparina4.ru
A. V KOLOTOVKINA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: alexandrager@mail.ru
N. M FAIZULLINA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: n_faizullina@oparina4.ru
E. A KALININA
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: e_kalinina@oparina4.ru
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