IMPACT OF CHRONIC ENDOMETRITIS ON THE OUTCOMES OF ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS: MORPHOFUNCTIONAL AND MOLECULAR GENETIC FEATURES


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The literature review analyzes the impact of chronic endometritis on the reproductive system and outcomes of assisted reproductive technology programs. It discusses difficulties in the diagnosis of this disease, the morphological features of the implantation endometrium, and the data available in the literature on the expression of some genes encoding proinflammatory cytokines, growth factors, and apoptotic processes affecting endometrial receptivity.

Full Text

Restricted Access

About the authors

V. K TABOLOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tabol93@rambler.ru
Moscow

I. E KORNEEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: irina.korneeva@inbox.ru
Moscow

References

  1. Корнеева И.Е. Современная концепция диагностики и лечения бесплодия в браке: Дис.. д-ра мед. наук. М.; 2003. 280 с.
  2. Fatemi H.M., Kasius J.C., Timmermans A., van Disseldorp J., Fauser B.C., Devroy P., Broekmans F.J. Prevalence of unsuspected uterine cavity abnormatilies diagnosed by office hysteroscopy prior to in vitro fertilization. Hum. Reprod. 2010; 25(8): 1959-65.
  3. Кондриков Н.И. Структурно-функциональные изменения эндометрия под воздействием стероидных гормонов. Практическая гинекология. 1999; 1: 20-5.
  4. Jonston-Macananny E.B., Hartnett J., Engmann L.L., Nulsen J.C., Sanders M.M., Benadiva C.A. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil. Steril. 2010; 93: 437-41.
  5. Kasius J.C., Fatemi H.M., Bourgain C., Sie-Go D.M., Eijkemans R.J., Fauser B.C. et al. The impact of chronic endometritis on reproductive outcome. Fertil. Steril. 2011; 96(6): 1451-6.
  6. Кулаков В.И., Леонов Б.В., Кузьмичев Л.Н., ред. Лечение женского и мужского бесплодия. Вспомогательные репродуктивные технологии. М.: МИА; 2005. 592 с.
  7. Железнов Б.И. Хронический неспецифический эндометрит в клинико-морфологическом аспекте. В кн.: Материалы 7-го Всесоюзного съезда патологоанатомов. Ташкент; 1983: 148-9.
  8. Железнов Б.И. Структурные изменения слизистой оболочки матки и функции яичников при хроническом эндометрите. Акушерство и гинекология. 1977; 4: 3-7.
  9. Rotterdam H. Chronic endometritis. A clinicopathologic study. Pathol. Annu. 1978; 13(2): 209-31.
  10. Greenwood S.M., Moran J.J. Chronic endometritis: morphologic and clinical observations. Obstet. Gynecol. 1981; 58: 176-84.
  11. ВОЗ. Международная статистическая классификация болезней и проблем, связанных со здоровьем. X пересмотр. М.; 2004: 53.
  12. Czernobilsky B. Endometritis and infertility. Fertil. Steril. 1978; 30: 119-30.
  13. Cicinelli E., De Ziegler D., Nicoletti R., Colafiglio G., Saliani N., Resta L. et al. Chronic endometritis: correlation among hysteroscopic, histologic and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertil. Steril. 2008; 89(3): 677-84.
  14. Kitaya K., Yasuo T. Abberent expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod. Pathol. 2010; 23: 1136-46.
  15. Kitaya K. Prevalens of chronic endometritis in recurrent miscarriages. Fertil. Steril. 2011; 95: 1156-8.
  16. Adegboyega P.A., Pey Y., McLarty J. Relationship between eosinophils and clinical endometritis. Hum. Pathol. 2010; 41: 33-7.
  17. Matteo M., Cicinelli E., Greco P., Massenzio F., Baldini D., Falagario T. et al. Abnormal pattern of lymphocyte subpopulations in the endometrium of infertile women with chronic endometritis. Am. J. Reprod. Immunol. 2009; 61: 322-9.
  18. Kitaya K., Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am. J. Reprod. Immunol. 2011; 66(5): 410-5.
  19. Kitaya K., Yasuo T. Inter-observer and intra-observer variability in immunohistochemical detection of endometrial stromal plasmacytes in chronic endometritis. Exp. Ther. Med. 2013; 5(2): 485-8.
  20. Vicetti Miguel R.D., Chivukula M., Krishnamurti U., Amortegui A.J., Kant J.A., Sweet R.L. et al. Limitations of the criteria used to diagnose histologic endometritis in epidemiologic pelvic inflammatory disease research. Pathol. Res. Pract. 2011; 207(11): 680-5.
  21. Devi Wold A.S., Pham N., Arichi A. Anatomic factors in recurrent pregnancy loss. Semin. Reprod. Med. 2006; 24: 25-32.
  22. Fatemi H.M., Popovic-Todorovic B., Ameryckx L., Bourgain C., Fauser B., Devroey P. In vitro fertilization pregnancy in a patient with proven chronic endometritis. Fertil. Steril. 2009; 91(4): 1293; e9-11.
  23. La Monica R., Hartnett J., Engman L.R., Sanders M.M., Maier D., Benadiva C. Immunohistochemistry confirms the presens of chronic endometritis in patient with recurrent implantation failure. Fertil. Steril. 2006; 86(Suppl.2): S280.
  24. Коган Е.А., Демура Т.А. Молекулярные и морфологические аспекты нарушений рецептивности эндометрия при хроническом эндометрите. Архив патологии. 2012; 3: 15-7.
  25. Psychoyos A., Mandon P. Scanning electron microscopy of the surface of the rat uterine epithelium during delayed implantation. J. Repod. Fertil. 1971; 26(1): 137-8.
  26. Quinn C., Casper R. Pinopodes: a questionable role in endometrial receptivity. Hum. Reprod. Update. 2009; 15: 22-36.
  27. Hilton D.J. LIF: Lots of interesting functions. Trends Biochem. Sci. 1992; 17: 72-6.
  28. Ohbayashi N., Ikeda O., Taira N., Yamamoto Y., Muromoto R., Sekine Y. et al. LIF and IL-6 - induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol. Pharm. Bull. 2007; 30(10): 1860-4.
  29. Stewart C.L. The role of LIF and other cytokines in regulating implantation in mammals. Ann. N.Y. Acad. Sci. 1994; 734: 157-65.
  30. Dimitriadis E., Nie G., Hannan P., Paiva P., Salamonsen L.A. Local regulation of implantation at the human fetal-maternal interface. Int. J. Dev. Biol. 2010; 54: 313-22.
  31. Serafini P.C., Silva I.D., Smith G.D., Motta E.L., Rocha A.M., Baracat E.C. Endometrial claudin-4 and LIF are associated with ART. Reprod. Biol. Endocrinol. 2009; 7: 30.
  32. Brinsden P.R., Alam V., de Moustier B., Engrand P. Recombinant human LIF does not improve implantation and pregnancy outcome after ART in women with recurrent unexplained implantation failure. Fertil. Steril. 2009; 91(4, Suppl.): 1445-7.
  33. Carpenter K.D., Korach K.S. Potential biological functions emerging from the different estrogen receptors. Ann. N. Y. Acad. Sci. 2006; 1092: 361-73.
  34. Дюжева Е.В., Калинина Е.А., Кузьмичев Л.Н., Коган Е.А. Иммуногистохимическое исследование эндометрия в программах ВРТ. Вестник Российского университета дружбы народов. Серия: Медицина. Акушерство и гинекология. 2009; 6: 98-104.
  35. Котиков А.Р., Али-Риза А.Э., Смирнов А.Н., Базина М.И., Блйчук Н.В., Али-Риза А.А. Экспрессия рецепторов эндометрия к эстрогенам и прогестерону при бесплодии, обусловленном хроническим эндометритом. Проблемы репродукции. 2006; 2: 7-10.
  36. Ma W.G., Song H., Das S.K., Paria B.C., Dey S.K. Estrogen is a critical determinat that specific the duration of uterine receptivity for implantation. Proc. Natl. Acad. Sci. USA. 2003; 100(5): 2963-8.
  37. Di Pietro C., Cicinelli E., Guglielmino M.R., Ragusa M., Farina M., Palumbo M.A., Cianci A. Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis. Am. J. Reprod. Immunol. 2013; 69(5): 509-17.
  38. Du X.X., Williams D.A. Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment. Blood. 1994; 83: 2023-30.
  39. Linjawi S., Li T.C., Tuckerman E.M., Blakemore A.I., Laird S.M. Expression of IL-11 receptors a and IL-11 protein I the normal fertile women with recurrent miscarriage. J. Reprod. Immunol. 2004; 64(1-2): 145-55.
  40. Guzeloglu-Kayisli O., Kayisli U.A., Taylor H.S. The role of growth factors and cytokines during implantation: endocrine and paracrine interactions. Semin. Reprod. Med. 2009; 57: 62-79.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies