COMPARATIVE ASSESSMENT OF METHODS FOR DIAGNOSIS OF THE ENDOMETRIUM IN POSTMENOPAUSAL PATIENTS WITH BREAST CANCER TAKING TAMOXIFEN


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Abstract

Objective. To comparatively assess diagnostic methods and endometrial changes by ultrasonography (USG) and hysteroscopy in postmenopausal patients taking tamoxifen. Subject and methods. One hundred tamoxifen-treated women with breast cancer who had the endometrium more than 5 mm thick were examined using USG. All the examinees were postmenopausal. The study evaluated the sensitivity, specificity, accuracy, and diagnostic efficiency of USG and hysteroscopy. Results. Ultrasound scanning revealed the following abnormalities: 38 cases of endometrial polyps, 11 cases of endometrial polyps concurrent with endometrial hyperplasia, and 51 cases of endometrial hyperplasia. Endometrial polyps were the most common diagnosis (in 59 cases of the 100 cases). Conclusion. The sensitivity and specificity of USG were 89.3 and 66.6%, respectively. Hysteroscopy had a very high sensitivity (96.97%) and specificity (91.2%).

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About the authors

I. O MAMIKONYAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: irulikjan@rambler.ru
Moscow

S. E SARKISOV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Moscow

M. A BOIKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Moscow

S. A GYURHYAN

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Moscow

Sh. N SATTAROV

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Moscow

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