ROLE OF AROMATASE GENE (CYP 19) POLYMORPHISM IN THE DEVELOPMENT OF INFERTILITY IN OBESE MALES

Objective. To study a relationship of aromatase gene (CYP 19) polymorphism to infertility, spermogram readings, and blood gonadotropic hormone levels in males with obesity. Subject and methods. The study included 75 males with a BMI of more than 30 kg/m 2: a study group consisted of 50 patients with idiopathic pathozoospermia; a control group comprised 35 fertile males. Aromatase gene (CYP) polymorphism was determined by polymerase chain reaction. Results. The obese males showed an association of fertility with their genotype containing of the A allele of rs749292(A/G) and rs2414096(A/G) polymorphisms in the CYP19A1 gene. The risk of infertility in these males increased rises by almost 2 times. Estimation of spermogram readings in patients with the homozygous form of rs2414096 and rs749292 polymorphisms (AA genotype) showed a considerable elevation in the ejaculate concentration of spermatozoa and their less mobility. The patients with the AA genotype by both polymorphisms had significantly lower levels of luteinizing hormone, follicle-stimulating hormone, and testosterone and a higher concentration of estrogen than those with the AG and GG genotypes. There were no differences in the alleles of rs936396 (C/T) polymorphism between both groups. Conclusion. The obese males exhibited an association of fertility with rs749292(A/G) and rs2414096(A/G) polymorphisms in the aromatase gene (CYP19A1).

male infertility, obesity, aromatase, CYP19A1 polymorphisms