PREMATURE OVARIAN FAILURE IS AN ENIGMA OF THE 21 st CENTURY


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Abstract

Premature ovarian failure (POF) is a symptom complex involving amenorrhea in less than 40-year-old patients with high levels of gonadotropins and low values of sex hormones. The precise nature of this pathology remains still vague and determined by genetic, chromosomal, autoimmune, infectious, toxic, and psychogenic factors, as well as defects in the structure of gonadotropins. The pathogenetic basis for the development of POF is the diminished total ovarian reserve that is nonphysiologic for a woman’s age, presumably due to an accelerated apoptotic process. The existing concepts of timely and premature ovarian aging have been recently reconsidered. Studying the role of mitochondrial dysfunction not only in the genesis of apoptosis, but also as a main trigger in the development of POF will be able to further elaborate new therapeutic approaches to treating this relatively rare, but quite mysterious abnormality.

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About the authors

G. I TABEYEVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and of Russia

Email: bambine@mail.ru
Moscow

N. N SHAMILOVA

Medline Service Clinic

Email: drshamilova@gmail.com
Moscow

N. A ZHAKHUR

Mother and Child Clinic

Email: natalia-jahour@mail.ru
Moscow

A. A POZDNYAKOVA

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and of Russia

Email: anna_pozd@mail.ru
Moscow

L. A MARCHENKO

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and of Russia

Email: l.a.marchenko@yandex.ru
Moscow

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