RESULTS OF AN INVESTIGATION OF THE PREVALENCE OF MAGNESIUM DEFICIENCY IN PREGNANT WOMEN

Background. No multicenter studies to assess the prevalence of Magnesium (Mg) deficiency in the general population, particularly among pregnant women have been previously conducted in Russia before previous study, where significant prevalence of magnesium deficiency (81,2%) in pregnant women was revealed. This study is the second wave of the program to confirm the findings of first wave in other populations leaving across the Russian Federation, with increased sample size. Objectives: the primary objective of this registry was to evaluate the incidence of the Mg deficiency in a pregnant population monitored in Russian polyclinics. Subject and methods. Pregnant women (at any trimester) aged over 18 years with clinical manifestations suggestive of Mg deficiency, such as uterine hypertonus, leg cramps, hestosis, neurasthenia and having signed the informed consent were included. Mg deficiency due to any other concomitant condition and participation to other concomitant clinical research were exclusion criteria. Data coming from medical records were collected at Visit 1 and visit 2 (1 month +/- 1 week): complete medical history; diagnosis of Mg deficiency confirmed by serum Mg level (<0.7mmol/l) routine laboratory tests performed in the course of current practice (blood count, Mg plasma determination and urinalysis) and evaluation of total score (superior ≥ 30) using a structured 28 questions self-administrated Magnesium Deficiency Questionnaire (MDQ). Spontaneous reports of adverse reactions were collected. The statistical tests were applied according to type of variable distribution and the estimation of equality of variances. Results. 2117 pregnant women, mean age 28,1±5,1 years were included in 200 sites in Russia. 2097 were receiving Mg and data of 2087 of them were analyzed (10 patients were excluded). The prevalence of Mg deficiency in pregnant women according to the blood plasma levels (<0.7 mmol) and MDQ was 58.4% (436/747) and 78.4% (1660/2117), respectively. Combining both criteria, the estimated prevalence of Mg deficiency was 80.9% (1713/2117). It was observed that physicians commonly prescribe different organic Mg salts to pregnant women with Mg deficiency as a routine practice. Conclusion. Thus, Mg was prescribed to 2097 pregnant women: 90.3% received Mg Citrate (1894/2097) and 9.7% (203/2097) Mg lactate. It was observed that organic Mg salts are commonly prescribed by physicians to pregnant women with established Mg deficiency and even if the study was not designed to evaluate efficacy of the prescribed treatments, statistically significant improvement in Mg deficiency signs in pregnant women receiving organic Mg salts was observed.

Mg, magnesium deficiency, magnesium citrate, pyridoxine