In vitro cytokine production by peripheral blood mononuclear cells in patients with recurrent miscarriage during alloimmunization
- Authors: Krechetova L.V1, Nikolaeva M.A1, Vanko L.V1, Ziganshina M.M1, Vtorushina V.V1, Khachatryan N.A1, Tetruashvili N.K1, Sukhikh G.T1
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Affiliations:
- Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Issue: No 5 (2014)
- Pages: 51-56
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247179
- ID: 247179
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Abstract
Full Text
About the authors
L. V Krechetova
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: k_l_v_@mail.ru
PhD in medical sciences, Head of Laboratory of Clinical Immunology
M. A Nikolaeva
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: nikolaeva_ma@mail.ru
Doctor of Science, Leading researcher, Laboratory of Clinical Immunology
L. V Vanko
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: LVanko@oparina4.ru
MD, Professor, Leading researcher, Laboratory of Clinical Immunology
M. M Ziganshina
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: mmz@mail.ru
junior researcher in Laboratory of Clinical Immunology
V. V Vtorushina
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: vtorushina@inbox.ru
PhD in medical sciences, doctor of laboratory diagnostics in Laboratory of Clinical Immunology
N. A Khachatryan
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: nelly1986@mail.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy
N. K Tetruashvili
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: tetrauly@mail.ru
MD, Head of the Department of Pregnancy Loss Prevention and Therapy
G. T Sukhikh
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: gtsukhikh@mail.ru
MD, Professor, Academician of Russian Academy of Medical Sciences, Director
References
- Thornton C.A. Immunology of pregnancy. Proc. Nutr. Soc. 2010; 69(3): 357-65.
- Farquharson R.G., Stephenson M.D., eds. Early pregnancy. Cambridge: Cambridge University Press; 2012.
- Carp H., ed. Reccurent pregnancy loss: causes, controversies and treatment. Informa UK Ltd; 2007. 290 p.
- Сидельникова В.М. Подготовка и ведение беременности у женщин с привычным невынашиванием. Методические пособия и клинические протоколы. М.: МЕДпресс-информ; 2011. 224 с.
- Mor G., Cardenas I., Abrahams V., Guller S. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann. N. Y. Acad Sci. 2011; 1221: 80-7.
- Romero R., Gotsch F., Pineles B., Kusanovic J.P. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr. Rev. 2007; 65(12, Pt 2): S194-202.
- Wegmann T.G., Lin H., Guilbert L., Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol. Today. 1993; 14(7): 353-6.
- Mowbray J.F., Gibbings C., Liddell H., Reginald P.W., Underwood J.L., Beard R.W. Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells. Lancet. 1985; 1(8435): 941-3.
- Liang P., Mo M., Li G.G., Yin B., Cai J., Wu T. et al. Comprehensive analysis of peripheral blood lymphocytes in 76 women with recurrent miscarriage before and after lymphocyte immunotherapy. Am. J. Reprod. Immunol. 2012; 68(2): 164-74.
- Saini V., Arora S., Yadav A., Bhattacharjee J. Cytokines in recurrent preg nancy loss. Clin. Chim. Acta. 2011; 412(9-10): 702-8.
- Raghupathy R., Makhseed M., Azizieh F., Omu A., Gupta M., Farhat R. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum. Reprod. 2000; 15(3): 713-8.
- Wilczynski J.R., Radwan P., Tchorzewski H., Banasik M. Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: does the immunization-dependent Th2 cytokine overbalance really matter? Arch. Immunol. Ther. Exp. (Warsz). 2012; 60(2): 151-60.
- Robertson S.A., Care A.S., Skinner R.J. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol. Reprod. 2007; 76(5): 738-48.
- Moreau P., Adrian-Cabestre F., Menier C., Guiard V., Gourand L., Dausset J. et al. IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes. Int. Immunol. 1999; 11(5): 803-11.