CLINICAL VALUE OF MARKERS FOR THE LIPID AND CYTOKINE STATUS IN REPRODUCTIVE-AGED PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS


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Abstract

Objective. To optimize the diagnosis of external genital endometriosis (EGE) in reproductive-aged patients, by determining the production of lipids and cytokines. Subject and methods. Ninety-six patients were examined and divided into 3 clinical groups: 1) 28 patients with Stages I-II EGE according to the r-AFS classification (1985); 2) 46 patients with Stages III-IV EGE; 3) a control group of 22 patients without endometriosis. All the patients underwent laparoscopy using the conventional procedure. The levels of lipoproteins, growth factors, CA-125, the endogenous level of NO as nitrite anion, and the activity of NOS were determined in their sera and peritoneal fluid. Results. The patients with different stages of EGE were found to have changes in molecular-cellular relationships at both systemic (serum) and local (peritoneal fluid) levels. Conclusion. The detected changes in the association of the lipid spectrum, growth factors, and angiogenic compounds are a theoretical ground for additional therapeutic measures to normalize metabolic processes in EGE.

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About the authors

V. A LINDE

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

MD, professor, director 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

N. V ERMOLOVA

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

MD, head of the gynecological department 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

L. V KOLESNIKOVA

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

PhD, doctor obstetrician-gynecologist of gynecology section 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

N. N SKACHKOV

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

PhD, senior researcher of Rostov Research 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

K. V SLESAREVA

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

junior researcher 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

I. V MARKARYAN

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

PhD, doctor obstetrician -gynecologist of gynecology section 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

N. A DRUKKER

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

Sc.D, chief researcher 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

E. N ERMOLENKO

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

laboratory doctor 344012, Russia, Rostov-on-Don, Mechnikov Str. 43

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