CURRENT CONCEPTS OF THE PATHOGENESIS OF DEEP INFILTRATIVE ENDOMETRIOSIS


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Abstract

This paper presents an update on the molecular genetic and epigenetic mechanisms of the pathogenesis of infiltrative endometriosis. It gives the morphological characteristics of endometriosis.

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About the authors

Olesya Nikolaevna Gorshkova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: o_gorshkova@oparina4.ru
Postgraduate student, Department of General Surgery 117997, Russia, Moscow, Ac. Oparina Str. 4

Yevgeniya Altarovna Kogan

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.N. Sechenov First Moscow State Medical University

Email: e_kogan@oparina4.ru
MD. Prof. I Pathology Department 117997, Russia, Moscow, Ac. Oparina Str. 4

Vladimir Dmitrievich Chuprynin

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_chuprynin@oparina4.ru
PhD, Head of the Department of General Surgery 117997, Russia, Moscow, Ac. Oparina Str. 4

Mikhail Viktorovich Melnikov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: m_melnikov@oparina4.ru
Candidate of Medical Sciences, Senior Researcher, Department of Surgery 117997, Russia, Moscow, Ac. Oparina Str. 4

Grigory Nikolayevich Khabas

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_khabas@oparina4.ru
Candidate of Medical Sciences, Head, Department of Combined and Complex Treatments 117997, Russia, Moscow, Ac. Oparina Str. 4

Anna Martunovna Khachatryan

I.N. Sechenov First Moscow State Medical University

Postgraduate Student, Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Faculty for Postgraduate Professional Training of Physicians 117997, Russia, Moscow, Ac. Oparina Str. 4

Elena Grigorevna Khilkevich

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.N. Sechenov First Moscow State Medical University

Email: e_khilkevich@oparina4.ru
leading researcher of General Surgery; professor of Department of Obstetrics, Gynecology, Perinatology and Reproductive 117997, Russia, Moscow, Ac. Oparina Str. 4

Abdul Baki Haitham

I.N. Sechenov First Moscow State Medical University

Email: h_abdul@oparina4.ru
Postgraduate Student, Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Faculty for Postgraduate Professional Training of Physicians 117997, Russia, Moscow, Ac. Oparina Str. 4

References

  1. Сидорова И.С., Коган Е.А., Зайратьянц О.В., Унанян А.Л., Леваков С.А. Новый взгляд на природу эндометриоза (аденомиоза). Акушерство и гинекология. 2002; 3: 32-8.
  2. Эндометриоз: Диагностика, лечение и реабилитация. Федеральные клинические рекомендации по ведению больных. М.; 2013.
  3. Адамян Л.В., Кулаков В.И., Андреева Е.Н. Эндометриозы. М.: Медицина; 2006. 416 с. [Adamyan L.V., Kulakov V.I., Andreeva E.N. Endometriosis. M.: Medicine; 2006. 416 p.]
  4. Баскаков В.П., Цвелев Ю.В., Кира Е.Ф. Эндометриоидная болезнь. СПб.: Изд-во Н-Л; 2002. 452 с.
  5. Payà V., Hidalgo-Mora J.J., Diaz-Garcia C., Pellicer A. Surgical treatment of rectovaginal endometriosis with rectal involvement. Gynecol. Surg. 2011; 8: 269-77.
  6. Wattiez A., Puga M., Albornoz J., Faller E. Surgical strategy in endometriosis. Best Pract. Res. Clin. Obstet. Gynaecol. 2013; 27(3): 381-92.
  7. Missmer S.A., Cramer D.W. The epidemiology of endometriosis. Obstet. Gynecol. Clin. North Am. 2003; 30: 1-19. vii
  8. Chapron C., Fauconnier A., Vieira M., Barakat H., Dousset B., Pansini V. et al. Anatomical distribution of deeply infiltrating endometriosis: surgical implications and proposition for a classification. Hum. Reprod. 2003; 18(1): 157-61.
  9. Kavallaris A., Chalvatzas N., Hornemann A., Banz C., Diedrich K., Agic A. 94months follow-up after laparoscopic assisted vaginal resection of septum rectovaginale and rectosigmoid in women with deep infiltrating endometriosis. Arch. Gynecol. Obstet. 2011; 283(5): 1059-64.
  10. Mabrouk M., Spagnolo E., Raimondo D., D’Errico A., Caprara G., Malvi D. et al. Segmental bowel resection for colorectal endometriosis: is there a correlation between histological pattern and clinical outcomes? Hum. Reprod. 2012; 27(5): 1314-9.
  11. Dassen H., Punyadeera C., Kamps R., Delvoux B., Van Langendonckt A., Donnez J. et al. Estrogen metabolizing enzymes in endometrium and endometriosis. Hum. Reprod. 2007; 22(12): 3148-58.
  12. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология. М.: МИА; 2001. 592 с.
  13. Аганезова Н.В. Планирование семьи. СПб.: СПбМАПО; 2004. 72 с.
  14. Meuleman C., Vandenabeele B., Fieuws S., Spiessens C., Timmerman D., D’Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil. Steril. 2009; 92(1): 68-74.
  15. Сидорова И.С., Коган Е.А., Унанян А.Л. Эндометриоз тела матки и яичников. М.: ММА им. И.М. Сеченова; 2007. 30 с.
  16. Nawroth F., Rahimi G., Nawroth C., Foth D., Ludwig M., Schmidt T. Is there an association between septate uterus and endometriosis? Hum. Reprod. 2006; 21(2): 542-4.
  17. Endometriosis & Dioxin Copyright 2009 Endometriosis Association.
  18. Баранов В.С., Иващенко Т.Э., Швед Н.Ю., Крамарева Н.Л., Асеев М.В. Генетические аспекты профилактики и лечения эндометриоза. Пособие для врачей. Айламазян Э.К., ред. СПб.: Изд-во Н-Л; 2004. 24 с.
  19. Ищенко А.И., Кудрина Е.А., Станоевич И.В., Бахвалова А.А., Ромаданова Ю.А. Современные проблемы наружного генитального эндометриоза. Акушерство и гинекология. 2007; 5: 67-73
  20. Dalsgaard T., Hjordt Hansen M.V., Hartwell D., Lidegaard O. Reproductive prognosis in daughters of women with and without endometriosis. Hum. Reprod. 2013; 28(8): 2284-8.
  21. Campo S., Campo V., Gambadauro P. Is a positive family history of endometriosis a risk factor for endometrioma recurrence after laparoscopic surgery? Reprod. Sci. 2014; 21(4): 526-31.
  22. Ищенко А.И., Кудрина Е.А. Эндометриоз: диагностика и лечение. М.: ГЭОТАР-МЕД; 2002. 104 с.
  23. Kogan E., Grechukhina O., Demura T., Unanjan A., Sidorova I. Morphogenetic relationships between foci of adenomyosis and basalis of eutopic endometrium. Virchows Arch. 2009; 455(Suppl.): S15. (Abstracts of the 22nd European Congress of Pathology. September 4-9, 2009. Florence, Italy.)
  24. Pittatore G., Moggio A., Benedetto C., Bussolati B., Revelli A. Endometrial adult/ progenitor stem cells: pathogenetic theory and new antiangiogenic approach for endometriosis therapy. Reprod. Sci. 2014; 21(3): 296-304.
  25. Kaei N., Masakazy N., Yukie K., Akitoshi T., Wakana A., Akitoshi Y. et al. Aberrant expression of apoptosis - related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod. Sci. 2011; 18(3): 206-18.
  26. Paul Dmowski W., Braun D.P. Immunology of endometriosis. Best Pract. Res. Clin. Obstet. Gynaecol. 2004; 18(2): 245-63.
  27. Vinatier D., Dufour P., Oosterlynck D. Immunological aspects of endometriosis. Hum. Reprod. Update. 1996; 2(5): 371-84.
  28. Ota H., Igarashi S., Hatazawa J., Tanaka T. Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis. Fertil. Steril. 1997; 68(1): 23-8.
  29. Кондриков Н.И. Концепция метапластического происхождения эндометриоза: современные аспекты. Акушерство и гинекология. 1999; 4: 10-3.
  30. Mechsner S., Weichbrodt M., Riedlinger W.F., Bartley J., Kaufmann A.M., Schneider A., Köhler C. Estrogen and progestogen receptor positive endometriotic lesions and disseminated cells in pelvic sentinel lymph nodes of patients with deep infiltrating rectovaginal endometriosis: a pilot study. Hum. Reprod. 2008; 23(10): 2202-9.
  31. Адамян Л.В., Бургова Е.Н., Сонова М.М., Осипова А.А., Арсланян К.Н., Поддубная О.Н. Окислительный стресс и генитальный эндометриоз. Проблемы репродукции. 2008; 4: 6-9.
  32. Коган Е.А., Унанян А.Л., Демура Т.А., Гречухина О.М., Сидорова И.С., Киселева В.И. Клинико-морфологические параллели и молекулярные аспекты морфогенеза аденомиоза. Архив патологии. 2008; 70(5): 8-12
  33. Giudice L.C., Evers J.L.H., Healy D.L., eds. Endometriosis: science and practice. Wiley-Blackwell; 2012. 600 p.
  34. Guo S.W. Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studies. Mol. Hum. Reprod. 2005; 11(10): 729-43.
  35. Guo S.W. The association of endometriosis risk and genetic polymorphisms involving dioxin detoxification enzymes: a systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2006; 124(2): 134-43.
  36. Zondervan K.T., Cardon L.R. Designing candidate gene and genome-wide case-control association studies. Nat. Protoc. 2007; 2(10): 2492-501.
  37. Wu Y., Halverson G., Basir Z., Strawn E., Yan P, Guo S.W. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am. J. Obstet. Gynecol. 2005; 193(2): 371-80.
  38. Fischer C.P., Kayisili U., Taylor H.S. HOXA10 expression is decreased in endometrium of women with adenomyosis. Fertil. Steril. 2011; 95(3): 1133-6.
  39. Xue Q., Lin Z, Yin P., Milad M.P., Cheng Y.H., Confino E. et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5'CpG island in endometriosis. J. Clin. Endocrinol. Metab. 2007; 92(8): 3261-7.
  40. Munro S.K., Farquhar C.M., Mitchell M.D., Ponnampalam A.P. Epigenetic regulation of endometrium during the menstrual cycle. Mol. Hum. Reprod. 2010; 16(5): 297-310.
  41. Pan Q., Luo X., Toloubeydokhti T., Chegini N. The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression. Mol. Hum. Reprod. 2007; 13(11):797-806.
  42. Kuokkanen S., Chen B., Ojalvo L., Benard L., Santoro N., Pollard J.W. Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometrium. Biol. Reprod. 2010; 82(4): 791-801.
  43. Wang W.T., Zhao Y.N., Han B.W., Hong S.J., Chen Y.Q. Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis. J. Clin. Endocrinol. Metab. 2013; 98(1): 281-9.
  44. Teague E.M., Print C.G., Hull M.L. The role of microRNAs in endometriosis and associated reproductive conditions. Hum. Reprod. Update. 2010; 16(2): 142-65.
  45. Унанян А.Л., Сидорова И.С., Коган Е.А., Демура Т.А., Демура С.А. Активный и неактивный аденомиоз: вопросы патогенеза и патогенетической терапии. Акушерство и гинекология. 2013; 4: 10-3.
  46. Nisolle M., Casanas-Roux F., Anaf V., Mine J.M., Donnez J. Morphometric study of the stromal vascularisation in peritoneal endometriosis. Fertil. Steril. 1993; 59(3): 681-4.
  47. Donnez J., Smoes P., Gillerot S., Casanas-Roux F., Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum. Reprod. 1998; 13(6): 1686-90.
  48. Nisolle M., Casanas-Roux F., Donnez J. Immunohistochemical analysis of proliferative activity and steroid receptor expression in peritoneal and ovarian endometriosis. Fertil. Steril. 1997; 68: 912-9.
  49. Köhler G., Lorenz G. Zur Korrelation von enoskopischem und histologischem Bild der Endometriose. Endometriose. 1991; 4: 56-60.
  50. Brosens I.A. Is mild endometriosis a progressive disease? Hum. Reprod. 1994; 9: 2209-11.
  51. Schweppe K.W. Aktive und inaktive Endometriose-eine prognose - und therapierelevante Differentialdiagnose. Zentralbl. Gynäkol. 1999; 121: 330-5.
  52. Viscomi F.A., Dias R., De Luca L., Franco M.F., Ihlenfeld M.F. Correlation between laparoscopic aspects and glandular hystological findings of peritoneal endometriotic lesions. Rev. Assoc. Med. Bras. 2004; 50: 344-8.
  53. Strehl J.D., Hackl J.,Wachter D.L., Klingsiek P., Burghaus S., Renner S.P. et al. Correlation of histological and macroscopic findings in peritoneal endometriosis. Int. J. Clin. Exp. Pathol. 2013; 7(1): 152-62.
  54. Коган Е.А., Сидорова И.С., Унанян А.Л., Демура Т.А., Хасигов П.З., Киселев В.И. Участие матриксных металлопротеиназ в патогенезе аденомиоза и возможные пути его фармакологической коррекции. Молекулярная медицина. 2007; 2: 20-5.
  55. Guo S.W. Association of endometriosis risk and genetic polymorphisms involving sex steroid biosynthesis and their receptors: a meta-analysis. Gynecol. Obstet. Invest. 2006; 61: 90-105.
  56. Адамян Л.В., Зайратьянц О.В., Максимова Ю.В., Мурдалова З.Х. Новые патогенетические аспекты распространенного инфильтративного эндометриоза: теории и практика. Проблемы репродукции. 2010; 4: 31-6.
  57. Бурлев В.А. Эктопический эндометрий: пролиферативная активность и апоптоз у больных с активной и неактивной формами перитонеального эндометриоза. Проблемы репродукции. 2012; 6: 7-13

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