ANTI-ANNEXIN V ANTIBODIES IN WOMEN WITH RECURRENT MISCARRIAGE


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Abstract

Objective. To analyze the association of the presence of anti-annexin V antibodies with reproductive failures in women with recurrent miscarriage. Subject and methods. One hundred and fifty-five pregnant women, including 119 ones diagnosed as having recurrent miscarriage and 34 women with physiological pregnancy, were examined. The level of the antibodies was determined using enzyme immunoassay kits (Orgentec, Germany). Results. The detection rate of anti-annexin V antibodies was increased in the women with recurrent miscarriage as compared to the control group of those with physiological pregnancy. In the recurrent miscarriage group, the frequency of anti-annexin V antibodies was higher than that of anti-phospholipid and anti-ß2 glycoprotein antibodies. Conclusion. Anti-annexin V antibodies are an independent risk factor identified in women with recurrent miscarriage and confirm the need for their determination in routine practice for the examination of women with recurrent miscarriage.

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About the authors

Sergey Vladimirovich Chepanov

D.O. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences

Email: chepanovsv@gmail.com
laboratory doctor, laboratory of immunology 199034, Russia, St. Petersburg, Mendeleyevskaya line 3

Tatiana Nikolaevna Shlyachtenko

D.O. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences

Email: tatnicshl@mail.ru
MD, Senior Researcher, Laboratory of Immunology 199034, Russia, St. Petersburg, Mendeleyevskaya line 3

Marina Sabirovna Zainulina

D.O. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences

Email: zainulina@yandex.ru
Doctor of medical sciences, deputy director for medical and scientific work 199034, Russia, St. Petersburg, Mendeleyevskaya line 3

Marina Ivanovna Mirashvili

D.O. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences

Email: Mmirashvili@yandex.ru
resident 199034, Russia, St. Petersburg, Mendeleyevskaya line 3

Dmitry Igorevich Sokolov

D.O. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences

Email: falcojugger@yandex.ru
Doctor of biological sciences, leading researcher 199034, Russia, St. Petersburg, Mendeleyevskaya line 3

Sergey Alekseevich Selkov

D.O. Ott Research Institute of Obstetrics and Gynecology, Northwestern Branch, Russian Academy of Medical Sciences

Email: selkovsa@mail.ru
Doctor of medical sciences, head of the laboratory of immunology 199034, Russia, St. Petersburg, Mendeleyevskaya line 3

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