THERAPY FOR ASSOCIATED UROGENITAL INFECTIONS WITH REGARD TO CURRENT INDICATORS OF ANTIBIOTIC RESISTANCE OF INFECTIOUS AGENTS


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Abstract

Objective. To study the efficacy, safety, and tolerability of the combined drug safocid (secnidazole, azithromycin, fluconazole) in the therapy of associated urogenital infections. Subject and methods. The study enrolled 50 patients with uncomplicated associated urogenital infections (urogenital trichomoniasis, chlamydial genitourinary infection, urethritis, and/or cervicitis caused by M. genitalium, bacterial vaginosis, and urogenital candidiasis). N. gonorrhoeae, T. vaginalis, and opportunistic microorganisms were identified by a culture method; C. trachomatis and M. genitalium were by a polymerase chain reaction assay. Bacterial vaginosis was diagnosed using the Amsel criterion. Results. Eradication of the causative agents of sexually transmitted infections, such as T. vaginalis, С. trachomatis, and M. genitalium, was achieved in 98% of the examinees. The efficiency of therapy for urogenital candidiasis and bacterial vaginosis was 97.3 and 95.3%, respectively. Therapy compliance was noted in 100% of the patients. Adverse drug reactions were recorded in 2% of the patients. Conclusion. Safocid is an effective and safe drug to treat patients with uncomplicated associated urogenital infections, including those with low compliance to treatment.

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About the authors

M. R RAKHMATULINA

State Dermatovenereology and Cosmetology Research Center, Ministry of Health of Russia

Email: rahmatulinal@yandex.ru
MD 107076, Russia, Moscow, Korolenko str. 3 bld. 6

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