Promises for using the possibilities of determining the level of follicular oxidative stress as a success criterion of assisted reproductive technology programs


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Abstract

The article gives an update on the importance of the oxidative stress factor determining the success of assisted reproductive technology programs, as well as the quality of oocytes and embryos. Oxidative stress is defined as an imbalance between the pro-oxidant and anti-oxidant systems - the cause of the induction of oxidative stress is drastically increased reactive oxygen species (ROS) production and/or impaired antioxidant defense mechanisms. The review presents and discusses the data of studies into the dualistic nature of ROSs that are not only a maturation factor, but also perform a role of one of the major damaging factors during oocyte maturation. The induction of oxidative stress in the follicular antrum and fluid is shown to affect oocyte maturation and embryo fertilization and implantation during ovarian stimulation in the in vitro fertilization (IVF) programs. The review covers a controversial issue of whether measurements of the oxidation products of biological macromolecules in the blood and follicular fluid of patients may be used to predict IVF program success. It also discusses the impact of different ovarian stimulation protocols in the IVF/ICSI programs on the level of oxidative stress.

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About the authors

K. A Ivancha

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: kristina.christina@yandex.ru
graduate student

E. A Kalinina

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: e_kalinina@oparina4.ru
MD, Head of the Department of in vitro fertilization

M. Yu Vysokikh

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; A.N. Belozersky Research Institute of Physicochemical Biology

Email: m_vysokikh@oparina4.ru
PhD, Head of mitochondrial medicine research group, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russia, Head of aging molecular mechanisms group, A.N. Belozersky Research Institute of Physicochemical Biology.

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