Androgen-dependent alopecia in women: pathogenesis, clinical presentation, diagnosis, treatment


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Abstract

Androgen-dependent alopecia is characterized by diffuse progressive hair loss in the characteristic zones and has a negative impact on self-assessment, psychological well-being, and quality of life in women to a greater extent than in men. The paper highlights the etiology, pathogenesis, and clinical presentation of androgen-dependent alopecia in women and discusses its diagnosis and therapy.

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About the authors

Elena E. Grodnitskaya

Center for Family Planning and Reproduction, Moscow Healthcare Department

Email: elena1778@mail.ru
MD, PhD

Mark A. Kurtser

N.I. Pirogov Russian National Research Medical University

Email: m.kurtser@mcclinics.ru
MD, PhD, Professor, Correspondent Member of RAS, Department of Obstetrics and Gynecology, Faculty of Pediatrics

References

  1. Azziz R., Carmina E., Sawaya M.E. Idiopathic hirsutism. Endocr. Rev. 2000; 21(4): 347-62.
  2. Cash T.F., Price V.H., Savin R.C. Psychological effects of androgenetic alopecia on women: comparisons with balding men and with female control subjects. J. Am. Acad. Dermatol. 1993; 29: 568-75.
  3. Girman C.J., Hartmaier S., Roberts J., Bergfeld W., Waldstreicher J. Patient perceived importance of negative effects of androgenetic alopecia in women. J. Womens Health Gend. Based Med. 1999; 8: 1091-5.
  4. Thiedke C.C. Alopecia in women. Am. Fam. Physician. 2003; 67(5): 1007-14.
  5. Dinh Q.Q., Sinclair R. Female pattern hair loss: current treatment concepts. Clin. Interv. Aging. 2007; 2(2): 189-99.
  6. Ludwig E. Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br. J. Dermatol. 1977; 97: 247-54.
  7. Olsen E.A. The midline part: An important physical clue to the clinical diagnosis of androgenetic alopecia in women. J. Am. Acad. Dermatol. 1999; 40: 106-9.
  8. Gan D.C., Sinclair R.D. Prevalence of male and female pattern hair loss in Maryborough. J. Investig. Dermatol. Symp. Proc. 2005; 10: 184-9.
  9. Blume-Peytavi U., Blumeyer A., Tosti A., Finner A., Marmol V., Trakatelli M. et al. ; European Consensus Group. S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents. Br. J. Dermatol. 2011; 164(1): 5-15.
  10. Futterweit W., Dunaif A., Yeh H. C., Kingsley P. The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia. J. Am. Acad. Dermatol. 1988; 19(5, Pt 1): 831-6.
  11. Carmina E., Rosato F., Janni A., Rizzo M., Longo R.A. Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism. J. Clin. Endocrinol. Metab. 2006; 91(1): 2-6.
  12. Cousen P., Messenger A. Female pattern hair loss in complete androgen insensitivity syndrome. Br. J. Dermatol. 2010; 162(5): 1135-7.
  13. Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in Serum. J. Clin. Endocrinol. Metab. 1999; 84: 3666-72.
  14. Blumeyer A., Tosti A., Messenger A., Reygagne P., Del Marmol V., Spuls P.I. et al.; European Dermatology Forum (EDF). Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men. J. Dtsch. Dermatol. Ges. 2011; 9(Suppl. 6): S1-57.
  15. Whiting D.A., Jacobson C. Treatment of female androgenetic alopecia with minoxidil 2%. Int. J. Dermatol. 1992; 31(11): 800-4.
  16. Price V.H., Roberts J.L., Hordinsky M., Olsen E.A., Savin R., Bergfeld W. et al. Lack of efficacy of finasteride in postmenopausal women with androgetic alopecia. J. Am. Acad. Dermatol. 2000; 43(5, Pt 1):768-76.
  17. Whiting D.A., Waldstreicher J., Sanchez M., Kaufman K.D. Measuring reversal of hair miniaturization in androgenetic alopecia by follicular counts inhorizontal sections of serial scalp biopsies: results of finasteride 1 mg treatment of men and postmenopausal women. J. Investig. Dermatol. Symp. Proc. 1999; 4(3): 282-4.
  18. Shum K.W., Cullen D.R., Messenger A.G. Hair loss in women with hyperandrogenism: four cases responding to finasteride. J. Am. Acad. Dermatol. 2002; 47: 733-9.
  19. Trueb R.M. Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women. Dermatology. 2004; 209: 202-7.
  20. Peereboom-Wynia J.D., van der Willigen A.H., van Joost T., Stolz E. The effect of cyproterone acetate on hair roots and hair shaft diameter in androgenetic alopecia infemales. Acta Derm. Venereol. 1989; 69(5): 395-8.
  21. Vexiau P., Chaspoux C., Boudou P., Fiet J., Jouanique C., Hardy N., Reygagne P. Effects of minoxidil 2% vs. cyproterone acetate treatment on female alopecia: acontrolled, 12-month randomized trial. Br. J. Dermatol. 2002; 146(6): 992-9.
  22. Carmina E., Lobo R. A. Treatment of hyperandrogenic alopecia in women. Fertil. Steril. 2003; 79(1): 91-5.
  23. Sinclair R., Wewerinke M., Jolley D. Treatment of female pattern hair loss with oral antiandrogens. Br. J. Dermatol. 2005; 152(3): 466-73.

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