Recurrent miscarriage: Immunological aspects


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Abstract

The etiology of miscarriage is diverse and dependent on many factors. The basis for this is immune disorders in 50% of cases. Monocytes and macrophages play a large role in maintaining immunological tolerance. These cells determine trophoblast invasion success, uterine spiral artery remodeling, and vasculature formation in branching and unbranching angiogenesis. Only adherence to all the above terms gives rise to the specific cytokine and cell balance in placental tissue, which governs the normal development of the placenta and fetus.

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About the authors

Nataliya Vladimirovna Batrak

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia; Ivanovo State Medical Academy, Ministry of Health of Russia

Email: batrakn@inbox.ru
graduate student; assistant of the department of obstetrics and gynecology, medical genetics

Anna Ivanovna Malyshkina

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia; Ivanovo State Medical Academy, Ministry of Health of Russia

Email: ivniimid@ivnet.ru
MD, director; head of the department of obstetrics and gynecology, medical genetics

Nataliya Vladimirovna Kroshkina

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia

Email: ivniimid@ivnet.ru
candidate of biology, research associate

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