Efficiency of using epigen intim in combination with a radiowave surgery technique to treat preinvasive cervical neoplasias in reproductive-aged women


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To study the efficiency of using epigen intim in combination with a radiowave surgery technique to treat preinvasive cervical neoplasias in reproductive-aged women. Subject and methods. After comprehensively examined, 52 patients with H-SIL and c-r in situ of the cervix uteri underwent its electric conization using a radiowave surgery apparatus. To prevent inflammatory complications and to stimulate regeneration, the cervix uteri was treated with epigen intim within 10 days before and after destruction. Results. High-risk human papillomavirus (HPV) was detected in 48 women; 4 were infected with low-risk HPV. After medical therapy in the preoperative period, a reduction in the signs of inflammation was revealed by optical coherence tomography under colposcopic control (OCT colposcopy). Postdestruction healing of the cervix uteri also occurred without inflammatory complications and accompanied by minor bloody or sanious discharge. Posttreatment monitoring showed that 96% of the women were completely healthy. Conclusion. Cervical radiowave destruction in combination with epigen intim can avoid postoperative inflammatory complications and optimize reparative processes after surgical treatment.

Full Text

Restricted Access

About the authors

Olga Vladimirovna Kachalina

Nizhny Novgorod State Medical Academy

Email: yander24@bk.ru
Ph.D., associate professor of the department of obstetrics and gynecology

Tatiana Simonovna Kachalina

Nizhny Novgorod State Medical Academy

MD, professor of the department of obstetrics and gynecology

Natalia Mikhailovna Shakhova

Nizhny Novgorod State Medical Academy

MD, professor of the department of obstetrics and gynecology

Darya Dmitrievna Eliseeva

Nizhny Novgorod State Medical Academy

Email: dd-bundina@yandex.ru
clinical intern of the department of obstetrics and gynecology

Gular Asif Mikailova

Nizhny Novgorod State Medical Academy

Email: g.mikailova90@mail.ru
kyzy, clinical intern of the department of obstetrics and gynecology

References

  1. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., Thun M.J. Cancer statistics, 2008. CA Cancer J. Clin. 2008; 58(2): 71-96.
  2. Кулаков В.И., Паавонен Й., Прилепская В.Н. Профилактика рака шейки матки. Руководство для врачей. М.: МЕДпресс-информ; 2008: 6-15. [Kulakov V.I., Paavonen J., Prilepskaya V.N. Prevention of cervical cancer. Guide for Physicians. M.: MEDpress-Inform; 2008: 6-15.]
  3. Чиссов В.И., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2010 году (заболеваемость и смертность). М.; 2012. 260 с. [Chissov V.I., Starinskiy V.V., Petrova G.V. Malignancies in Russia in 2010 (morbidity and mortality). M.; 2012: 260 p.]
  4. Bosch F.X., Burchell A.N., Schiffman M., Giuliano A.R., de Sanjose S., Bruni L. et al. Epidemiology and natural history of human papillomavirus infections and time-specific implications in cervical neoplasia. Vaccine. 2008; 25(Suppl.10): K1-16.
  5. Краснопольский В.И., Зароченцева Н.В., Белая Ю.М., Шипулина О.Ю., Михеева И.В., Серова О.Ф., Мельник Т.Н. Инфицированность вирусом папилломы человека среди девочек-подростков в Московской области. Российский вестник акушера-гинеколога. 2010; 10(5): 46-9. [Krasnopolskiy V.I., Zarochentseva N.V., Belaya Yu.M., Shipulina O.Yu., Mikheeva I.V., Serova O.F., Melnik T.N. Infection with human papilloma virus among adolescent girls in Moscow region. Russian bulletin of obstetrician-gynecologist. 2010; 10(5): 46-9.]
  6. Spartz H., Lehr E., Zhang B., Roman A., Brown D.R. Progression from productive infection to integration and oncogenic transformation in human papillomavirus type 59-immortalized foreskin keratinocytes. Virology. 2005; 336(1): 11-25.
  7. Дмитриев Г.А., Биткина О.А. Папилломавирусная инфекция. М.: Медицинская книга; 2006. 80 с. [Dmitriev G.A., Bitkina O.A. HPV infection. M.: Medical book; 2006: 80 p.]
  8. Ершов В.А., Нарвская О.В. Фоновые процессы и неоплазия эпителия шейки матки. СПб.: Человек; 2007. 79 с. [Ershov V.A., Narvskaya O.V. Background processes and cervical epithelial neoplasia. St. Petersburg: Chelovek; 2007: 79 p.]
  9. Fisher M., Rosenfeld W.D., Burk R.D. Cervicovaginal human papillomavirus infection in suburman adolescents and young adults. J. Pediatr. 2001; 119(5): 821- 5.
  10. Нейштадт Э.Л., Крулевский В.А. Дифференциальная диагностика опухолей шейки матки. Руководство. СПб.: КультИнформПресс; 2012: 85-8. [Neyshtadt E.L., Krulevskiy V.A. Differential diagnosis of cervical cancer. Guide. St. Petersburg: KultInformPress; 2012: 85-8.]
  11. Новик В.И. Скрининг рака шейки матки. Практическая онкология. 2010; 11(2): 66-73. [Novick V.I. Cervical cancer screening. Practical Oncology. 2010; 11 (2): 66-73.]
  12. Манухин И.Б., Минкина Г.Н., Калинина В.С. Микробиоценоз влагалища и патология шейки матки. Возможности коррекции дисбиотических состояний. В кн.: Прилепская В.Н., ред. Поликлиническая гинекология. 3-е изд. М.: МЕДпресс-информ; 2008: 37-47. [Manukhin I.B., Minkin G.N., Kalinina V.S. // Microbiocenosis ofvagina and cervical pathology. Possibilities for correction of dysbiotic states. In: Prilepskaya V.N., ed. Outpatient Gynecology. 3rd ed. Moscow: 2004; 37-47.]
  13. Роговская С.И. Папилломавирусная инфекция у женщин и патология шейки матки. Руководство для практикующего врача. М.: ГЭОТАР-Медиа; 2005. [Rogovskaya S.I. HPV infection in women and cervical pathology. A guide for the practitioner. M.: GEOTAR-Media; 2005.]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Bionika Media