Changes in the hemostatic system in patients with hereditary connective tissue disorders in early pregnancy


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Abstract

Objective. To compare the parameters of coagulation hemostasis and fibrinolysis and the levels of fetoplacental unit hormones in young women in early pregnancy in relation to the degree of hereditary connective tissue disorders and thrombosis prophylaxis. Subject and methods. The parameters of coagulation hemostasis and fibrinolysis and the levels of fetoplacental unit hormones were studied and correlations between vascular resistance indices in the uteroplacental unit and hemostatic system parameters were determined in 418 patients with hereditary connective tissue disorders and in 313 pregnant women without these conditions. Results. The use of low-molecular-weight heparins in combination with dydrogesterone was found to improve the indicators of uteroplacental unit hormones in the patients with hereditary connective tissue disorders. Conclusion. Thrombosis prophylaxis and dydrogesterone therapy in early periods in patients with hereditary connective tissue disorders can improve uteroplacental unit parameters.

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About the authors

Eugenia Gennad’evna Kudinova

Novosibirsk State National Research University; Altai State Medical University, Ministry of Health of Russia

Candidate of Medicine, Assistant of the Department of Obstetrics and Gynecology, Medical Faculty of Novosibirsk state university; Doctoral student in the Faculty of Hematology and Blood Transfusion training and retraining students of Altai Medical University

Andrey Pavlovich Momot

Altai State Medical University, Ministry of Health of Russia; Altai Branch, Hematology Research Center, Ministry of Health of Russia

Doctor of Medicine, Professor of Altai Medical University; Director of Altai branch of the Federal state budgetary institution Hematology Research Center Ministry of Health

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