Prevention of coagulopathic bleeding during uterine sparing surgery
- Authors: Sinchikhin S.P.1, Magakyan S.G.1, Stepanyan L.V.1, Mamiev O.B.1
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Affiliations:
- Astrakhan State Medical Academy
- Issue: No 11 (2014)
- Pages: 116-120
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247326
- ID: 247326
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Abstract
Objective. To evaluate the efficacy of tranexam 1.0 g used before organ-sparing surgery in patients with fibrinolytic coagulation abnormalities. Subjects and methods. One hundred and twenty patients with uterine myoma in whom laparoscopic myomectomy had been performed by one surgical team were followed up. Their mean age was 32.5±3.7 years. The fibromatous nodules measured 3.0 to 5.5 cm and were subperitoneal or intermuscular; at the same time one of the nodules showed centripetal growth. The examinees were divided into two equal groups of 60 persons in each. According to the developed invention procedure (Priority Certificate dated 20 February 2014; Application No. 2014106575(010377), 30-45 minutes prior to surgery, the patients of one group received intravenous injections of 1.0 g of tranexam diluted in 200 ml of 0.9% of sodium chloride solution for 20-30 minutes. Tranexam was not administered to the patients of the other group. Blood loss volume was estimated using a gravimetric method and considering the changes in laboratory parameters. Results. There was a 2-3-fold decrease in total blood loss in the women who had received tranexam preoperatively as compared to those who had not. In addition to a clinical observation and gravimetric calculation of blood loss, laboratory tests also proved the positive effect of tranexam on its reduced perioperative amount. Conclusion. Tranexam 1.0 g used in patients with blood fibrinolytic coagulation abnormalities before organ-sparing surgery is effective and safe in preventing coagulopathic bleeding and reducing in total perioperative blood loss.
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About the authors
Sergei Petrovich Sinchikhin
Astrakhan State Medical Academy
Email: doc_sinchihin@rambler.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Therapeutics
Sarkis Gevorkvich Magakyan
Astrakhan State Medical Academy
Email: magakyan.s@yandex.ru
assistant of the Department of Obstetrics and Gynecology, Faculty of Therapeutics
Lusine Vardanovna Stepanyan
Astrakhan State Medical Academy
Email: lus-s84@mail.ru
PhD, assistant of Department of Obstetrics and Gynecology, Faculty of Therapeutics
Oleg Borisovich Mamiev
Astrakhan State Medical Academy
Email: mamievob@rambler.ru
MD, Professor of the Department of Obstetrics and Gynecology, Faculty of Therapeutics
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