THE NOTCH SIGNALING PATHWAY IN THE HUMAN PLACENTA DURING PHYSIOLOGICAL AND COMPLICATED PREGNANCY


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Abstract

The literature review gives data on the history of the discovery of the Notch signaling pathway, its molecular structure, cell localization, and functions of its major components, as well as those on the canonical and noncanonical pathways of their interaction, by specifying the basic steps in activating the structural components of the pathway. Particular emphasis is placed on the specific features of Notch signaling pathway functioning in the human placenta during physiological pregnancy; the specific features of the temporary and spatial expression of receptors and ligands in the placental Notch system, as well as its role in the course of placentation are described. The functions of the Notch signaling system in the structures of villous and extravillous trophoblasts are detailed; data on its role in the processes of trophoblast invasion, proliferation, and differentiation, as well as placental vasculogenesis and angiogenesis are given. The specific features of Notch system functioning in some pregnancy complications, mainly in preeclampsia, are depicted and the possible mechanisms by which the components of this system are involved in the development of pregnancy complications are also given.

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About the authors

Konstantin A. Pavlov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kpavlov@oparina4.ru
PhD in medicine, member of the 2nd Pathanatomy department 117997, Russia, Moscow, Ac. Oparina str. 4

Elena A. Dubova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_dubova@oparina4.ru
PhD in medicine, member of the 2nd Pathanatomy department 117997, Russia, Moscow, Ac. Oparina str. 4

AІexander I. Shchegolev

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru
PhD, Chief of pathology Department 117997, Russia, Moscow, Ac. Oparina str. 4

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