INTERLEUKIN-2 GENE POLYMORPHISM IN WOMEN WITH RECURRENT PREGNANCY LOSSES


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Abstract

Objective. To assess the role of interleukin-2 (IL-2) polymorphism in women with recurrent pregnancy loss. Subjects and methods. The distribution of the IL-2 alleles and genotypes of the polymorphic loci: -330 T>G (rs 2069762) and +166 G>T (rs 2069763) was studied in 90 women. Group 1 consisted of 30 patients with recurrent early losses (at less than 22 weeks’ gestation). Group 2 included 30 patients with multiple very early preterm labors (at 22 to 28 weeks’ gestation). Group 3 comprised 30 patients with uncomplicated pregnancy and a history of at least 2 full-term births (a control group). Results. There were significant differences in the distribution of the IL-2 genotypes and alleles: -330 T>G (rs 2069762) in the group of pregnant women with early miscarriage versus that of women with physiological pregnancy. Conclusion. Determination of IL-2 gene polymorphisms: -330 T>G (rs 2069762) when planning pregnancy makes it possible to identify a group at risk for early miscarriage for more careful pregravid preparation and optimization of pregnancy management tactics.

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About the authors

Evgeniya V. Alegina

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: aleginai@rambler.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy Moscow 117997, Ac. Oparina str. 4, Russia

Nana K. Tetruashvili

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy Moscow 117997, Ac. Oparina str. 4, Russia

Anna A. Agadjanova

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, leading researcher of the Department of Pregnancy Loss Prevention and Therapy Moscow 117997, Ac. Oparina str. 4, Russia

Andrey E. Donnikov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
Ph.D. in medical sciences, leading researcher of Laboratory of molecular genetic methods Moscow 117997, Ac. Oparina str. 4, Russia

Dmitrii Y. Trophimov

Academician V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_troflmov@oparina4.ru
Ph.D. in medical sciences, Head of Laboratory of molecular genetic methods Moscow 117997, Ac. Oparina str. 4, Russia

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