The detection rate and pattern of endometrial hyperplasia in different age periods

Objective. To study the incidence rate and pattern of endometrial hyperplasia (EH) from the data available at V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation. Subjects and methods. 11,219 histology records during a 5-year period (2008-2012), presented by the workers of Morbid Anatomy Department One, Research Center of Obstetrics, Gynecology, and Perinatology, were retrospectively analyzed. Results. Among all the types of EH, there was a predom inance of simple EH (SEH); its proportion was as h igh as 70%; complex EH (CEH) and associated EH (AEH) were diagnosed in every 5 and 10 cases, respectively. SEH was mainly characterized by diffuse endometrial changes; CEH was by focal lesions more frequently in the presence of SEH, less frequently in the presence of the unaltered endometrium. In the past 5 years, there has not been a change in the pattern of EH or a rise in its morbidity although there is no tendency towards its reduction. The peak of SEH and CEH was noted in the menopause transition and that of AEH was seen at the age of 30-40 years. Endometrioid adenocarcinoma (EA) is generally detected in postmenopause; 13.5% of all cases occur at a reproductive age. Conclusion. No reduced incidence of EH and the rather high rate of occurrence of AEH and EA at a reproductive age support the need to implement a cancer prevention program that encompasses qualified morphological evaluation of the endometrium, identification of high cancer risk groups, and improvement of approaches to therapy.

endometrial hyperplasia, endometrioid adenocarcinoma, incidence