ANTIANEMIC DRUGS IN THE COMBINATION TREATMENT OF SMALL PELVIC INFLAMMATORY DISEASES
- Authors: VINOGRADOVA O.P1, KUZNETSOVA M.N2, BIRYUCHKOVA O.A3
-
Affiliations:
- Penza Institute for Postgraduate Training of Physicians, Ministry of Health of Russia
- M.I. Kalinin Samara Clinical Hospital
- N.F. Filatov Penza Regional Children's Clinical Hospital
- Issue: No 2 (2015)
- Pages: 49-52
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247380
- ID: 247380
Cite item
Abstract
Objective. To provide a pathogenetic rationale for the use of the iron preparation sorbifer durules to treat small pelvic inflammatory diseases (SPID) in relation to the processes of free radical oxidation. Subjects and methods. Reproductive-aged women who formed a control group of donors and a study group of patients with SPID were examined. Serum iron levels were colorimetrically determined using a Cobas Integra automated biochemical analyzer. Transferrin and ferritin concentrations were immunoturbidimetrically estimated with the same analyzer. A RANDOX test system was applied to determine the plasma total antioxidant status. Hemoglobin levels were measured using a Sysmex KX-21N hematological analyzer. IL-4, IL-8, TNF-a, INF-a, INF-y, and neopterin were analyzed by a competitive enzyme immunoassay employing a Multiskan Ascent semiautomated vertical photometer (Thermo Electron). Results. The significant decrease in the levels of serum iron, hemoglobin, and transferrin as the manifestations of endogenous intoxication syndrome become severe and blood loss is absent confirms that this cohort of patients develops anemia of inflammation. Conclusion. The findings suggest that there is a reduction in the level of serum iron and its depot concentration in SPID, which calls for correction with sorbifer durules.
Full Text
About the authors
O. P VINOGRADOVA
Penza Institute for Postgraduate Training of Physicians, Ministry of Health of Russia
Email: о_ vinogradova69@mail.ru
Penza
M. N KUZNETSOVA
M.I. Kalinin Samara Clinical Hospital
Email: marinak1007@yandex.ru
Samara
O. A BIRYUCHKOVA
N.F. Filatov Penza Regional Children's Clinical Hospital
Email: iolgabox@yahoo.com
Penza
References
- Пекарев О.Г. Эффективность терапии воспалительных заболеваний органов малого таза. Гинекология. 2011; 13(2): 19-22.
- Хаятова З.Б. Клиника, диагностика и лечение воспалительных заболеваний органов малого таза у женщин репродуктивного возраста с анемией: автореф. дис.. д-ра мед. наук. Новосибирск; 2014: 6-12.
- Долгов В.В., Луговская С.А., Морозова Т.В., Почтарь М.Е. Лабораторная диагностика анемий. М.; Тверь: «Триада»; 2009. 148 с.
- Baker J.F., Ghio A.J. Iron homoeostasis in rheumatic disease. Rheumatology (Oxford). 2009; 48(11): 1339-44.
- Ganz T. Iron in innate immunity: starve the invaders. Curr. Opin. Immunol. 2009; 21(1): 63-7.
- Чеснокова Н.П., Михайлова А.В., ред. Инфекционный процесс. М.: «Академия естествознания»; 2006. Available at: http://www.rae.ru/ru/pub- lishing/mono07_42.html. Дата обращения 28.08.2014г.
- Андреичев Н.А., Балеева Л.В. Железодефицитные состояния и железодефицитная анемия. Вестник современной клинической медицины. 2009; 3: 60-5.
- Краснопольский В.И., Буянова С.Н., Щукина Н.А. Гнойные воспалительные заболевания придатков матки. М.; 1995.
- WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva: World Health Organization; 2011. (WHO/NMH/NHD/MNM/11.1). Available at: http://www.who.int/vmnis/indicators/haemoglobin_ru.pdf.