ASSOCIATION OF TNF AND TGFB1 GENE POLYMORPHISMS WITH A PREDISPOSITION TO VAGINITIS IN REPRODUCTIVE-AGED WOMEN


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Abstract

Objective. To establish the distribution of allelic variants of the immune response genes associated with a predisposition to vaginitis in reproductive-aged women. Subjects and methods. A polymerase chain reaction (PCR) assay was used to investigate 22 allelic variants of the immune response genes in 96 women with vaginitis. A comparison group consisted of 60 apparently healthy women without signs of genital tract inflammatory diseases. Peripheral blood samples were examined. Results. The distribution of 22 allelic alleles of the immune response genes was established in the apparently healthy women and in the patients with vaginitis. The allelic variants of TNF (rs361525) and TGFB1 (rs1800469) polymorphisms, which were associated with the development of vaginitis, were ascertained. Both allelic variants result in the decreased TNF and TGFB1 mRNA expression, they are more common in the population, which can also cause the high prevalence of this gynecological disease. Conclusion. There was a positive association of the C allele of the TGFB1-509 C>T locus (OR =1.8; CI: 1.12.9) and a negative association of the A allele of the TNF-238 G>A locus (OR = 0.21; CI: 0.07-0.68) with a predisposition to inflammatory diseases of the lower female genital tract.

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About the authors

O. V Burmenskaya

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru
Ph.D., researcher of the laboratory of molecular genetic methods 117997, Russia, Moscow, Ac. Oparina str. 4

Guldana Raufovna Bairamova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bayramova@mail.ru
MD, Clinic supervisor 117997, Russia, Moscow, Ac. Oparina str. 4

V. V Kadochnikova

State Research Center Institute of Immunology, Federal Biomedical Agency of Russia

Email: vladavi@mail.ru
PhD, researcher, Laboratory of Human Histocompability Genetics, State Research Center Institute of Immunology 115478, Russia, Moscow, Kashirskoye sh. 24 bld. 2

V. N Prilepskaya

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: VPrilepskaya@mail.ru
MD, Professor, Deputy Director for Science 117997, Russia, Moscow, Ac. Oparina str. 4

D. Yu Trofimov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_troflmov@oparina4.ru
DSc, Head of laboratory of molecular genetic methods 117997, Russia, Moscow, Ac. Oparina str. 4

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