EFFICIENCY OF SKIN WOUND HEALING WHEN USING THE SYNERGID COMPOSITION OF CALCIUM IN AN INCISED WOUND MODEL


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Abstract

The provision of certain trace elements plays an important role in the wound healing process. This investigation has studied the effects of the synergid composition of calcium with zinc, copper, manganese, boron, magnesium, and vitamin D (calcemin advance) in an incised wound model. Administration of the agent as an aqueous suspension for 21 days resulted in a reduction in the mean time to complete wound healing at 6 days as compared to the control (water, p < 0.05). As this took place, the mean wound area was significantly different between the groups, just starting on day 9 of the experiment (p values in the range of0.00013-0.047). The increased rate of wound healing when using the synergid combination of calcium was accompanied by the elevated levels of type I collagen fibers in the wound area (by +20% as compared with the control; p = 0.00056). Histological analysis attested the acceleration of a cicatricial tissue maturation process and pointed to a decreased inflammatory response in the ripening connective tissue and to improved wound epithelialization.

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About the authors

Vadim I. Demidov

Ivanovo State Medical Academy, Ministry of Health of Russia

MD, Associate Professor of Histology and Pathological Anatomy 153000, Russia, Ivanovo, Sheremetyevsky pr. 8

Nikolay Yu. Zhidomorov

Ivanovo State Medical Academy, Ministry of Health of Russia

Ph.D., assistant professor of pharmacology and clinical pharmacology 153000, Russia, Ivanovo, Sheremetevsky pr. 8

Ivan Yurievich Torshin

Moscow Institute of Physics and Technology

candidate of physic-mathematical sciences, associate professor of the Department of Intelligent Systems 141700, Russia, Moscow region, Dolgoprudniy, Institutskiy per. 9

Andrew Yu. Volkov

Institute for UNESCO

Ph.D., Senior Scientist, Scientific Adviser, Russian Satellite Center of Trace Element 153000, Russia, Ivanovo, Sheremetyevsky pr. 8

Olga Alekseevna Gromova

Ivanovo State Medical Academy

Email: unesco.gromova@gmail.com
MD, professor of Department of Pharmacology and Clinical Pharmacology 153000, Russia, Ivanovo, Sheremetyevsky pr. 8

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