Reproductive disorders in female patients with respiratory organ tuberculosis

Objective: to study the specif ic features of reproductive disorders in female patients with active respiratory organ tuberculosis (ROT) during their stay at specialized hospital. Subjects and methods. Two hundred and sixty-eight women: 1) 142 patients with active ROT (a study group); 2) 126 healthy women (a control group) were examined. General and specialized studies (collection of history data; examination; analysis of respiratory organ X-ray tomographic findings; clinical and biochemical analyses of blood; coagulogram; microbiological and molecular genetic examinations of sputum and menstrual blood; examination of the level of female sex hormones; cytological and molecular genetic studies of vaginal discharge) were performed. Results. 44.4% of the patients with ROT were found to have menstruation irregularities; 64.1% had genital mucosal biocenotic changes that clinically showed themselves as recurrent inflammatory diseases; the rate of cervical abnormalities was 49.3%. 54.9% had inflammatory diseases of the internal genitalia, which were characterized by an acute course and possible lympho- and hematogenous dissemination of tuberculosis infection, which permit them to be assigned to a group at risk for genital tuberculosis. Conclusion. The timely, rationally chosen chemotherapy and the diagnosis and treatment of reproductive disorders decrease the probable dissemination of tuberculosis infection and the development of genital tuberculosis, promote the prevention of cancer of the cervix uteri, improve reproductive health, and increase the future reproductive potential.

respiratory organ tuberculosis, female reproductive health, inflammatory diseases of the vagina and small pelvic organs, menstrual irregularities, tuberculous salpingitis