THE ANTIOXIDANT SYSTEM AND THE PROCESSES OF LIPID PEROXIDATION IN WOMEN WITH POSTMENOPAUSE SLEEP DISORDERS


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Abstract

Objective. To study lipid peroxidation (LPO) processes and the antioxidant defense (AOD) system in women with postmenopause sleep disorders. Subjects and methods. Fifty-seven postmenopausal women, including 23 and 34 without and with sleep disorders, respectively, were examined. The latter group was divided into two subgroups: patients with insomnia (n = 18) and those with insomnia and snoring (n = 16). The investigation used spectrophotometric studies of the LPO-AOD system. The intergroup differences were estimated using the nonparametric criterion. Results. The patients with insomnia had elevated levels of LPO substrates and primary products while those with insomnia and snoring had higher levels of LPO substrates and thiobarbituric acid active products than the control group. The oxidative stress coefficient was 3.2 and 4.7 times greater than the reference value in the patients with insomnia and in those with insomnia and snoring, respectively. Conclusion. The findings suggest the development of evident oxidative stress in patients with postmenopause sleep disorders.

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About the authors

L. I KOLESNIKOVA

Research Center for Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
professor, director Irkutsk 664003, Timiryaseva str. 16, Russia

I. M MADAEVA

Research Center for Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
director of Somnological Centre Irkutsk 664003, Timiryaseva str. 16, Russia

N. V SEMENOVA

Research Center for Family Health and Human Reproduction Problems

Email: natkor_84@mail.ru
PhD, researcher of Research Center Irkutsk 664003, Timiryaseva str. 16, Russia

E. I SOLODOVA

Research Center for Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
obstetrician-gynecologist Irkutsk 664003, Timiryaseva str. 16, Russia

M. A DARENSKAYA

Research Center for Family Health and Human Reproduction Problems

Email: iphr@sbamsr.irk.ru
researcher Irkutsk 664003, Timiryaseva str. 16, Russia

References

  1. Сухих Г.Т., Сметник В.П., Ильина Л.М., Юренева С.В., Коновалова В.Н., Балан В.Е. и др. Практические рекомендации по применению заместительной гормональной терапии у женщин в пери- и постменопаузе. Климактерий. 2009; 2: 10-29
  2. Kalleinen N. Sleep and menopause - hormone therapy and sleep deprivation. Painosalama Oy - Turku, Finland; 2008. 78p.
  3. Ощепкова Е.В., Дмитриев В.А., Титов В.Н., Дугин С.Ф., Рогоза А.Н. Показатели перекисного окисления липидов и антиоксидантной активности на ранних стадиях гипертонической болезни. Кардиоваскулярная терапия и профилактика. 2008; 7(6): 277.
  4. Дедов И.И., Колесникова Л.И., Бардымова Т.П., Прокофьев С.А., Иванова О.Н., Гнусина С.В. Этнические особенности сахарного диабета у народов Прибайкалья. Бюллетень СО РАМН. 2008; 28(1): 16-20.
  5. Lee W.L., Huang J.Y., Shyur L.F. Phytoagents for сancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxid. Med. Cell. Longev. 2013; 2013: 925804.
  6. Меньщикова Е.Б., Зенков Н.К., Ланкин В.З., Бондарь И.А., Труфакин В.А. Окислительный стресс. Патологические состояния и заболевания. Новосибирск: АРТА; 2008. 284с.
  7. Мадаева И.М. Формирование адаптивных и дизадаптивных реакций метаболической системы при обструктивных нарушениях дыхания во время сна: автореф. дисс.. д-ра мед. наук. Иркутск; 2009. 43с.
  8. Ramanathanl L., Hu S., Frautschy S.A., Siegel J.M. Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions without impairing spontaneous alternation behavior. Behav. Brain Res. 2010; 207(2): 305-9.
  9. Suer C., Dolu N., Artis A.S., Sahin L., Yilmaz A., Cetin A. The effects of longterm sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats. Neurosci. Res. 2011; 70(1): 71-7.
  10. Thamaraiselvi K., Mathangi D.C., Subhashini A.S. Effect of increase in duration of REM sleep deprivation on lipid peroxidation. Int. J. Biol. Med. Res. 2012; 3(2): 1754-9.
  11. Baysal E., Taysi S., Aksoy N., Uyar M., Celenk E., Karatas Z.A. et al. Serum paraoxonase, arylesterase activity and oxidative status in patients with obstructive sleep apnea syndrome (OSAS). Eur. Rev. Med. Pharmacol. Sci. 2012; 16(6): 770-4.
  12. Kolesnikova L., Madaeva I., Semenova N., Vlasov B., Grebenkina L., Darenskaya M. Antioxidant potential of the blood in men with obstructive sleep breathing disorders. Bull. Exp. Biol. Med. 2013; 154(6): 731-3.
  13. Franco C.M., Lima A.M., Ataide L. Jr., Lins O.G., Castro C.M., Bezerra A.A. et al. Obstructive sleep apnea severity correlates with cellular and plasma oxidative stress parameters and affective symptoms. J. Mol. Neurosci. 2012; 47(2): 300-10.
  14. Simiakakis M., Kapsimalis F., Chaligiannis E., Loukides S., Sitaras N., Alchanatis M. Lack of effect of sleep apnea on oxidative stress in obstructive sleep apnea syndrome (OSAS) patients. PLoS One. 2012; 7(6): e39172.
  15. Hachul D.E., Campos H., Brandao L.C., D'Almeida V., Grego B.H., Bittencourt L.R. et al. Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Climacteric. 2006; 9(4): 312-9.
  16. Gulec M., Ozkol H., Selvi Y., Tuluce Y., Aydin A., Besiroglu L. et al. Oxidative stress in patients with primary insomnia. Prog. Neuropsychopharmacol. Biol. Rsychiatry. 2012; 37(2): 247-51.
  17. Liang B., Li Y.-H., Kong H. Serum paraoxonase, arylesterase activities and oxidative status in patients with insomnia. Eur. Rev. Med. Pharmacol. Sci. 2013; 17(18): 2517-22.
  18. Колесникова Л.И., Гребенкина Л.А., Олифиренко В.П., Осипова Е.В., Долгих М.И., Курашова Н.А. и др. Программа для расчета коэффициента окислительного стресса на основе параметров системы перекисного окисления липидов - антиоксидантной защиты в крови. Патент № 2011617323 от 21.09.2011.
  19. Sanchez-Rodriguez M.A., Zacarias-Flores M., Arronte-Rosales A., Correa-Muno E., Mendoza-Nunez V.M. Menopause as risk factor for oxidative stress. Menopause. 2012; 19(3): 361-7.
  20. Mendoza C.C., Zamarripa C.A.J. Menopause induces oxidative stress. Available at: http://dx.doi.org/10.5772/52082
  21. Подгорнова Н.А., Гречканев Г.О. Показатели перекисного окисления липидов и антиоксидантной системы защиты как прогностический критерий тяжести течения климактерического синдрома. Российский вестник акушера-гинеколога. 2010; 2: 13-5.
  22. Ogunro P.S., Bolarinde A.A., Owa O.O., Salawu A.A., Oshodi A.A. Antioxidant status and reproductive hormones in women during reproductive, perimenopausal and postmenopausal phase of life. Afr. J. Med. Med. Sci. 2014; 43(1): 49-57.
  23. Reimund E. The free radical flux theory of sleep. Med. Hypotheses. 1994; 43(4): 231-3.
  24. Mendoza-Nunez V.M., Beristain-Perez A., Perez-Vera S.P., Altamirano-Lozano M.A. Age-related sex differences in glutathione peroxidase and oxidative DNA damage in a healthy Mexican population. J. Womens Health. 2010; 19(5): 919-26.
  25. Tan D.X., Manchester L.C., Terron M.P., Flores L.J., Reiter R.J. One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species? J. Pineal Res. 2007; 42(1): 28-42.
  26. Анисимов В.Н., Виноградова И.А. Старение женской репродуктивной системы и мелатонин. СПб.; 2008. 44с.
  27. Колесникова Л.И., Мадаева И.М., Семенова Н.В., Сутурина Л.В., Бердина О.Н., Шолохов Л.Ф., Солодова Е.И. Патогенетическая роль мелатонина при нарушениях сна у женщин климактерического периода. Бюллетень экспериментальной биологии и медицины. 2013;156(7): 117-9.
  28. Мадаева И.М., Колесникова Л.И., Петрова В.А., Шевырталова О.Н., Шолохов Л.Ф. Изменения процессов перекисного окисления липидов и системы антиокислительной защиты у пациентов с синдромом обструктивного апноэ сна. Патологическая физиология и экспериментальная терапия. 2009; 3: 24-7.

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