EXPERIENCE WITH MICRONIZED PROGESTERONE THERAPY FOR MISCARRIAGE IN PREGNANT WOMEN WITH UTERINE MYOMA


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Objective. To evaluate the efficiency of the intravaginal route of administration of the natural micronized progesterone prajisun in the therapy of threatened miscarriage in patients with uterine myoma. Subjects and methods. Examinations were made in 64 pregnant women aged 28 to 46 years with uterine myoma and threatened miscarriage at 6-14 weeks’ gestation. There were two groups: 1) 48 women who received the micronized progesterone prajisun intravaginally and 2) 16 had dydrogesterone. All the patients underwent clinical, dynamic ultrasound, and Doppler examinations. Results. The symptoms of threatened miscarriage were abolished and pregnancy preservation was achieved in all the patients of both groups. The pregnant women of the study group had a chance to use the agent at a later time and were satisfied with its intravaginal administration. No side effects were recorded; dynamic vaginal pH measurement demonstrated the maintenance of its readings in the range of 3.5- 4.4. Conclusion. The micronized progesterone prajisun is an effective component of threatened miscarriage therapy for patients with uterine myoma.

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作者简介

Alfia Iashchuk

Bashkir State Medical University, Ministry of Health of Russia

Email: alfiya_galimovna@mail.ru
MD, professor, Head of Obstetrics and Gynecology Department

Liliana Dautova

Bashkir State Medical University, Ministry of Health of Russia

Email: Lili.d5@yandex.ru
Candidate of Medicine, Assoc. Prof. of Obstetrics and Gynecology Department

Yazilya Shevchenko

City Clinical Hospital Eight

Deputy Chief Physician

Raisa Naftulovich

Bashkir State Medical University, Ministry of Health of Russia

Email: raisanaftulovich@mail.ru
PhD. assistant of the Department of Obstetrics and Gynecology № 2

Alla Tyurina

Bashkir State Medical University, Ministry of Health of Russia

Email: tyurina.alla2016@yandex.ru
graduate of the Department of Obstetrics and Gynecology № 2

Vadim Murzin

Bashkir State Medical University, Ministry of Health of Russia

Email: pointy_still@mail.ru
resident

参考

  1. Буянова С.Н., Логутова Л.С., Щукина Н.А., Мгелиашвили М.В., Юдина Н.В., Гукасян С.А., Ахвледиани К.Н., Чечнева М.А., Ермолаева Е.Е. Миомэктомия вне и во время беременности: показания, особенности хирургической тактики и анестезии, предоперационная подготовка и реабилитация. Российский вестник акушера-гинеколога. 2013; 13(2): 95-100.
  2. Duhan N. Current and emerging treatments for uterine myoma - an update. Int. J. Womems Health. 2011; 3: 231-41.
  3. Рымашевский А.Н., Самсонов А.Е., Терехина Л.А., Юдина Е.Д., Нечаюк В.И. Оптимизация родоразрешения беременных с миомой матки. Российский вестник акушера-гинеколога. 2011; 11(3): 49-51.
  4. Даутова Л.А., Ящук А.Г., Иванова К.Н., Гарипов Д.Р. Прегравидарная подготовка в успешной реализации репродуктивного потенциала. В кн.: Материалы I Общероссийской конференции с международным участием «Перинатальная медицина: от прегравидарной подготовки к здоровому материнству и детству». Санкт-Петербург, 9-11 декабря 2014г. СПб.; 2014.
  5. Гончарова С.В., Башмакова Н.В. Потеря беременности: патогенетическая терапия и ее исходы у женщин группы высокого риска. Вопросы гинекологии, акушерства и перинатологии. 2014; 13(3): 19-26.

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