COMBINED ORAL CONTRACEPTIVES: NOT ONLY CONTRACEPTION
- Authors: AGANEZOVA N.V1, AGANEZOV S.S1
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Affiliations:
- I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
- Issue: No 6 (2015)
- Pages: 118-123
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247446
- ID: 247446
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Abstract
The paper analyzes an update on the non-contraceptive aspects of the effects of estrogen-gestagen contraceptives. It provides evidence for the therapeutic effects of combined contraceptives against androgen-dependent dermopathy and also describes the marked therapeutic effects of combined oral contraceptives with chlormadinone acetate in acne and hirsutism. The results of studies of the protective effect of estrogen-gestagen contraceptives in preventing skin aging are given. The mechanisms of action of combined contraceptives on mood and libido are discussed and the benefits of an estrogen-gestagen agent with chlormadinone acetate are depicted.
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About the authors
N. V AGANEZOVA
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: aganezova@mail.ru
MD, Associate Professor, Department of Obstetrics and Gynecology Saint Petersburg 191015, Kirochnaya str. 41, Russia
S. S AGANEZOV
I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia
Email: aganezov@mail.ru
PhD, Associate Professor, Department of Obstetrics and Gynecology Saint Petersburg 191015, Kirochnaya str. 41, Russia
References
- Аганезова Н.В. Психосоциальные и медицинские аспекты консультирования современной женщины при выборе метода контрацепции. Вопросы гинекологии, акушерства и перинатологии. 2009; 8(5): 20-6.
- Дильман В.М. Четыре модели медицины. Л.: Медицина; 1987. 288с.
- Kanda N., Watanabe S. Regulatory roles of sex hormones in cutaneous biology and immunology. J. Dermatol. Sci. 2005; 38(1): 1-7.
- Zouboulis C.C., Makrantonaki E. Hormonal therapy of intrinsic aging. Rejuvenation Res. 2012;15(3): 302-12.
- Schramm G., Heckes B. Switching hormonal contraceptives to a chlormadinone acetate-containing oral contraceptive. The Contraceptive Switch Study. Contraception. 2007; 76(2): 84-90.
- Arowojolu A.O., Gallo M.F., Lopez L.M., Grimes D.A. Combined oral contraceptive pills for treatment of acne. Cochrane Database Syst. Rev. 2012; (7): CD004425. doi: 10.1002/14651858.CD004425.pub6.
- Plewig G., Cunliffe W.J., Binder N., Höschen K. Efficacy of an oral contraceptive containing EE 0.03 mg and CMA 2 mg (Belara) in moderate acne resolution: a randomized, double-blind, placebo-controlled phase III trial. Contraception. 2009; 80(1): 25-33.
- Kerscher M., Reuther T., Bayrhammer J., Schramm G. Effects of an oral contraceptive containing chlormadinone and ethinylestradiol on acne-prone skin of women of different age groups: an open-label, single-centre, phase IV study. Clin. Drug Investig. 2008; 28(11): 703-11.
- Kerscher M., Reuther T., Krueger N., Buntrock H. Effects of an oral contraceptive containing chlormadinone acetate and ethinylestradiol on hair and skin quality in women wishing to use hormonal contraception. J. Eur. Acad. Dermatol. Venereol. 2013; 27(5): 601-8.
- Raudrant D., Rabe T. Progestogens with antiandrogenic properties. Drugs. 2003; 63(5): 463-92.
- Anthuber S., Schramm G.A., Heskamp M.L. Six-month evaluation of the benefits of the low-dose combined oral contraceptive chlormadinone acetate 2 mg/ethinylestradiol 0.03 mg in young women: results of the prospective, observational, non-interventional, multicentre TeeNIS study. Clin. Drug Investig. 2010; 30(4): 211-20.
- Стеняева Н.Н., Хритинин Д.Ф. Гормональная контрацепция и женская сексуальность. Акушерство и гинекология. 2013; 7: 106-11.
- Pastor Z., Holla K., Chmel R. The influence of combined oral contraceptives on female sexual desire: a systematic review. Eur. J. Contracept. Reprod. Health Care. 2013; 18(1): 27-43.
- Schaffir J. Hormonal contraception and sexual desire: a critical review. J. Sex Marital Ther. 2006; 32(4): 305-14.
- Azzouni F., Godoy A., Li Y., Mohler J. The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. Adv. Urol. 2012; 2012: 530121.
- Huber J.C., Heskamp M.L., Schramm G.A. Effect of an oral contraceptive with chlormadinone acetate on depressive mood: analysis of data from four observational studies. Clin. Drug Investig. 2008; 28(12): 783-91.
- Masters W.H., Johnson V.E. Homosexuality in perspective. Toronto; New York: Bantam Books; 1979.
- Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry. 2009; 65(9): 732-41.
- Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., Lanctôt K.L. A meta-analysis of cytokines in major depression. Biol. Psychiatry. 2010; 67(5): 446-57.
- Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 2009; 71(2): 171-86.
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