Novelty in the treatment of infertility in premature ovarian failure


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Abstract

Persistent infertility is a leading complaint in women with premature ovarian failure (POF) after disease manifestation. This paper analyzes 3 systematic reviews that discuss different therapeutic approaches applied to this category of patients, as well as an innovative technique to overcome infertility in patients with POF. The current concept of timely and premature ovarian aging provides a new possibility for developing effective and safe treatments for infertility in this category of patients.

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About the authors

Anna A. Pozdnyakova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: anna_pozd@mail.ru
3rd year graduate student

Natalia A. Zhakhur

Mother and Child Clinic

Email: natalia-jahour@mail.ru
PhD, an obstetrician-gynecologist Moscow

Maria B. Ganichkina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mariaganichkina@yandex.ru
2nd year resident

Larisa A. Marchenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l.a.marchenko@yandex.ru
MD, professor, leading researcher at the Department of Gynecological Endocrinology

References

  1. Tartagni M., Cicinelli E., De Pergola G., De Salvia M.A., Lavopa C., Loverro G. Effects of pretreatment with estrogens on ovarian stimulation with gonadotropins in women with premature ovarian failure: a randomized, placebocontrolled trial. Fertil. Steril. 2007; 87(4): 858-61.
  2. Gleicher N., Barad D.H. Dehydroepiandrosterone (DHEA) supplementation in dimished ovarian reserve (DOR). Reprod. Biol. Endocrinol. 2011; 9: 67.
  3. Габибуллаева З.Г. Клинико-генетическая характеристика больных с преждевременной недостаточностью яичников: дисс.. канд. мед. наук. М.; 2008. 163c.
  4. Александрова Н.В. Прогностическая значимость методов оценки овариального резерва у женщин с преждевременной недостаточностью яичников: дис.. канд. мед. наук. М.; 2006. 201c. [Aleksandrova N.V. Prognostic importance of methods for assessing ovarian reserve in women with premature ovarian failure. Diss. Moscow; 2006. 201 p. (in Russian)]
  5. Conway G.S., Kaltsas G., Patel A., Davies M.C., Jacobs H.S. Characterization of idiopathic premature ovarian failure. Fertil. Steril. 1996; 65(2): 337-41.
  6. Mehta A.E., Matwijiw I., Lyons E.A., Faiman C. Noninvasive diagnosis of resistant ovary syndrome by ultrasonography. Fertil. Steril. 1992; 57(1): 56-61.
  7. Nelson L.M., Anasti J.N., Kimzey L.M., Defensor R.A., Lipetz K.J., White B.J. et al. Development of luteinized graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure. J. Clin. Endocrinol. Metab. 1994; 79(5): 1470-5.
  8. Nelson L.M., Kimzey L.M., White B.J., Merriam G.R. Gonadotropin suppression for the treatment of karyotypically normal spontaneous premature ovarian failure: a controlled trial. Fertil. Steril. 1992; 57(1): 50-5.
  9. Anasti J.N., Kimzey L.M., Defensor R.A., White B., Nelson L.M. A controlled study of danazol for the treatment of karyotypically normal spontaneous premature ovarian failure. Fertil. Steril. 1994; 62(4): 726-30.
  10. Hirota Y., Ohara S., Nishizawa H., Tada S., Udagawa Y. Evaluation of laparoscopic management and clinical outcome in women with premature ovarian failure. Gynecol. Endosc. 2002; 11: 411-5.
  11. Di Pasquale E., Rossetti R., Marozzi A., Bodega B., Borgato S., Cavallo L. et al. Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure. J. Clin. Endocrinol. Metab. 2006; 91(5): 1976-9.
  12. Dixit H., Rao L.K., Padmalatha V.V., Kanakavalli M., Deenadayal M., Gupta N. et al. Missense mutations in the BMP15 gene are associated with ovarian failure. Hum. Genet. 2006; 119(4): 408-15.
  13. Ledig S., Röpke A., Haeusler G., Hinney B., Wieacker P. BMP15 mutations in XX gonadal dysgenesis and premature ovarian failure. Am. J. Obstet. Gynecol. 2008; 198(1): 84. e1-5.
  14. Moore R.K., Shimasaki S. Molecular biology and physiological role of the oocyte factor, BMP-15. Mol. Cell. Endocrinol. 2005; 234(1-2): 67-73.
  15. Horie K., Takakura K., Fujiwara H., Suginami H., Liao S., Mori T. Immunohistochemical localization of androgen receptor in the human ovary throughout the menstrual cycle in relation to oestrogen and progesterone receptor expression. Hum. Reprod. 1992; 7(2): 184-90.
  16. Табеева Г.И. Оценка андрогенного статуса при преждевременной недостаточности яичников и дифференциальный подход к лечению: дисс.. канд. мед. наук. М.; 2009. 202с. [Tabeeva G.I. Assessment of androgen status with premature ovarian failure, and a differential approach to treatment. Diss. Moscow; 2009 202 p. (in Russian)]
  17. Asch R., Balmaceda J., Ord T., Borrero C., Cefalu E., Gastaldi C., Rojas F. Oocyte donation and gamete intrafallopian transfer as treatment for premature ovarian failure. Lancet. 1987; 1(8534): 687.
  18. Oskarsson T., Edgar D.H., Whalley K.M., Mills J.A. Clinical and biochemical pregnancy in two respective recipients without ovarian function following gamete intrafallopian transfers using oocytes from a single donor. Scott. Med. J. 1990; 35(4): 114-5.
  19. Rotsztejn D.A., Remohi J., Weckstein L.N., Ord T., Moyer D.L., Balmaceda J.P., Asch R.H. Results of tubal embryo transfer in premature ovarian failure. Fertil. Steril. 1990; 54(2): 348-50.
  20. Abdalla H.I., Baber R.J., Kirkland A., Leonard T., Studd J.W. Pregnancy in women with premature ovarian failure using tubal and intrauterine transfer of cryopreserved zygotes. Br. J. Obstet. Gynaecol. 1989; 96(9): 1071-5.
  21. Massin N., Méduri G., Bachelot A., Misrahi M., Kuttenn F., Touraine P. Evaluation of different markers of the ovarian reserve in patients presenting with premature ovarian failure. Mol. Cell. Endocrinol. 2008; 282(1-2): 95-100.
  22. van Kasteren Y.M., Schoemaker J. Premature ovarian failure: a systematic review on therapeutic interventions to restore ovarian function and achieve pregnancy. Hum. Reprod. 1999; 5(5): 483-92.
  23. Жахур Н.А., Марченко Л.А., Бутарева Л.Б., Шахова М.А. Возможности восстановления фертильности у пациенток с преждевременной недостаточностью яичников. Проблемы репродукции. 2010; 1: 40-8. [Zhahur N.A., Marchenko L.A., Butareva L.B., Shahova M.A. Recovery of fertility in women with premature ovarian failure. Problemyi reproduktsii. 2010; 1: 40-8. (in Russian)]
  24. Ben J., Panay N. Premature ovarian insufficiency: how to improve reproductive outcome? Climacteric. 2013; 16(1): 1-5.
  25. Bidet M., Bachelot A., Touraine P. Premature ovarian failure: predictability of intermittent ovarian function and response to ovulation induction agents. Curr. Opin. Obstet. Gynecol. 2008; 20(4): 416-20.
  26. Scott R., Hofmann G. Prognostic assessment of ovarian reserve. Fertil. Steril. 1995; 63(1): 1-11.
  27. Тагиева Г.В. Роль аутоиммунного процесса в генезе преждевременного выключения функции яичников: дисс. канд. мед. наук. М.; 2005. 178c. [Tagiyeva G.V. The role of the autoimmune process in the genesis of premature ovarian ablation. Diss. Moscow; 2005. 178 p. (in Russian)]
  28. Rosen G.F., Stone S.C., Yee B. Ovulation induction in women with premature ovarian failure: a prospective, crossover study. Fertil. Steril. 1992; 57(2): 448-9.
  29. van Kasteren Y.M., Hundscheid R.D., Smits A.P., Cremers F.P., van Zonneveld P., Braat D.D. Familial idiopathic premature ovarian failure: an overrated and underestimated genetic disease? Hum. Reprod. 1999; 14(10): 2455-9.
  30. Tidey G.F., Nelson L.M., Phillips T.M., Stillman R.J. Gonadotropins enhance HLA-DR antigen expression in human granulosa cells. Am. J. Obstet. Gynecol. 1992; 167(6): 1768-73.
  31. Шамилова Н.Н. Клинико-прогностическое значение различных молекулярно-биологических маркеров при преждевременной недостаточности яичников: дисс. канд. мед. наук. М.; 2012. [Shamilova N.N. Clinical and prognostic value of various molecular biological markers in premature ovarian failure. Diss. Moscow; 2012. (in Russian)]
  32. Badawy A., Goda H., Ragab A. Induction of ovulation in idiopathic premature ovarian failure: a randomized double-blind trial. Reprod. Biomed. Online. 2007; 15(2): 215-9.
  33. Boumpas D., Chrousos G., Wilder R., Cupps T., Balow J. Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates. Ann. Intern. Med. 1993; 119(12): 1198-208.
  34. Check J., Katsoff B. Ovulation induction and pregnancy in a woman with premature menopause following gonadotropin suppression with the gonadotropin releasing hormone antagonist, cetrolix - a case report. Clin. Exp. Obstet. Gynecol. 2008; 35(1): 10-2.
  35. Griesinger G., Diedrich K., Tarlatzis B.C., Kolibianakis E.M. GnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis. Reprod. Biomed. Online. 2006; 13(5): 628-38.
  36. Марченко Л.А., Жахур Н.А., Бутарева Л.Б., Кузьмичев Л.Н., Микаелян В.Г. Сравнительный анализ стимуляции овуляции фоллитропином альфа на фоне применения агонистов гонадотропин-рилизинг-гормона или высоких доз этинилэстрадиола у больных с преждевременной недостаточностью яичников. Акушерство и гинекология. 2011; 2: 65-9. [Marchenko L.A., Zhakhur N.A., Butareva L.B., Kuzmichev L.N., Mikaelyan V.G. Comparative analysis of follitropin alpha ovulation stimulation in the use of gonadotropin-releasing hormone agonists or high-dose ethinyl estradiol in patients with premature ovarian failure. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2011; 2: 65-9. (in Russian)]
  37. Davis O., Ravnikar V. Ovulation induction with clomiphene citrate in a woman with premature ovarian failure. A case report. J. Reprod. Med. 1988; 33: 559-62
  38. Kawamura K., Cheng Y., Suzuki N., Deguchi M., Sato Y., Takae S. et al. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc. Natl. Acad. Sci. USA. 2013; 110(43): 17474-9.
  39. Ravn K. Grafted ovaries lead to successful pregnancy. Nature News. 30 September, 2013.
  40. Gleicher N., Weghofer A., Barad D.H. The role of androgens in follicle maturation and ovulation induction: friend or foe of infertility treatment? Reprod. Biol. Endocrinol. 2011; 9: 116.
  41. Mamas L., Mamas E. Premature ovarian failure and dehydroepiandrosterone. Fertil. Steril. 2009; 91(2): 644-6.
  42. Labrie F. DHEA, important source of sex steroids in men and even more in women. Prog. Brain Res. 2010; 182: 97-148.
  43. Yeung T., Li R., Lee V., Ho P., Ng E. A randomized double-blinded placebocontrolled trial on the effect of dehydroepiandrosterone for 16 weeks on ovarian response markers in women with primary ovarian insufficiency. J. Clin. Endocrinol. Metab. 2013; 98(1): 380-8.

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