Cell adhesion molecule expression by phagocytes as a criterion for the differential diagnosis of hypertensive disorders in pregnant women
- Authors: Panova I.A.1, Kudryashova A.V.1, Malyshkina A.I.1, Khlipunova D.A.1, Rokotyanskaya E.A.1
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Affiliations:
- V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
- Issue: No 7 (2015)
- Pages: 33-37
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247469
- ID: 247469
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Abstract
Objective. To propose new differential diagnostic criteria for arterial hypertension (AH) on the basis of an investigation of cell adhesion molecule expression by venous blood neutrophils and monocytes in pregnant women with different forms of this condition. Subjects and methods. Fifty women with preeclampsia (PE), 36 with chronic AH (CAH), 33 with CAH added by PE, and 45 control women were examined. Flow cytofluometry was used to determine the levels of CD11b +, CD49b +, CD99 + monocytes and neutrophils. Results. As compared to the control group, the patients with PE were found to have elevated CD49b + neutrophil levels; those with CAH had higher CH99 + neutrophils and lower CD11b + monocytes; those with CAH and PE had increased CD99 + and CD49 + neutrophil concentrations. The examined indicators are of informative value in the differential diagnosis of hypertensive disorders in pregnant women. Conclusion. The determination of the levels of CD11b +, CD49b +, CD99 + monocytes and neutrophils may be used as an additional diagnostic criterion in identifying the type of AH in pregnant women.
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About the authors
Irina Aleksandrovna Panova
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: ia_panova@mail.ru
doctor of medical sciences, head of Department of obstetrics and gynecology
Anna Vladimirovna Kudryashova
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: niimid.immune@mail.ru
doctor of biological sciences, senior researcher of the laboratory of clinical immunology
Anna Ivanovna Malyshkina
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: niimid@ivnet.ru
doctor of medical sciences, Director
Darya Alexandrovna Khlipunova
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: da_shutka_xa@mail.ru
postgraduate student in obstetrics and gynecology
Elena Arkadyevna Rokotyanskaya
V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia
Email: rokotyanskaya.ea@mail.ru
candidate of medical Sciences, scientific co-employees of the Department of obstetrics and gynecology
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