Obesity and reproductive function
- Authors: Grigoryan O.R.1, Andreeva E.N.1
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Affiliations:
- Endocrinology Research Center, Ministry of Health of Russia
- Issue: No 9 (2015)
- Pages: 14-19
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247470
- ID: 247470
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Abstract
Objective. To estimate the current attitude towards the impact of obesity on reproductive function from the data available in the literature. Subject and methods. Literature sources dedicated to estimates of the prevalence of obesity in different countries of the world, to the current view on the mechanism by which obesity affects fertility, and to approaches to treating obesity are reviewed. Results. The present-day literature data favor experts’ predictions that obesity rate will keep rising. The close relationship between obesity and reproductive dysfunction determines the relevance of the problem. Current drug therapy assists in achieving weight management goals, but does not completely rule out abnormal eating behaviors. Conclusion. Sibutramine havingpleiotropic effects is the drug of choice in controlling body weight. The drug can affect energy balance and correct eating behavior. These can expect a high therapeutic effect and patient compliance.
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About the authors
Olga R. Grigoryan
Endocrinology Research Center, Ministry of Health of Russia
Email: iceberg1995@mail.ru
MD, senior researcher of endocrine gynecology department with a group of screening and prevention of reproductive disorders
Elena N. Andreeva
Endocrinology Research Center, Ministry of Health of RussiaMD, professor, head of endocrine gynecology department with a group of screening and prevention of reproductive disorders
References
- Демидова Т.Ю. Редуксин - новое средство решения старых проблем! Диабет. Образ жизни. 2007; 4: 4-7. [Demidova T.Yu. Reduksin - new means of solving old problems! Diabet. Obraz zhizni. 2007; 4: 4-7. (in Russian)]
- Clark A.M., Ledger W., Galletly C., Tomlinson L., Blaney F., Wang X., Norman R.J. Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum. Reprod. 1995; 10(10): 2705-12.
- Chapman I.M., Wittert G.A., Norman R.J. Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clin. Endocrinol. (Oxf). 1997; 46(2): 175-81.
- Bilenka B., Ben-Shlomo I., Cozacov C., Gold C.H., Zohar S. Fertility, miscarriage and pregnancy after vertical banded gastroplasty operation for morbid obesity. Acta Obstet. Gynecol. Scand. 1995; 74(1): 42-4.
- Bohrer M., Kemmann E. Risk factors for spontaneous abortion in menotropin treated women. Fertil. Steril. 1987; 48(4): 571-5.
- Conway G.S., Agrawal R., Betteridge D.J., Jacobs H.S. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin. Endocrinol. (Oxf). 1992; 37(2): 119-25.
- Correa H., Jacoby J. Nutrition and fertility: some iconoclastic results. Am. J. Clin. Nutr. 1978; 31(8): 1431-6.
- Bates G.W., Whitworth N.S. Effect of body weight reduction on plasma androgens in obese, infertile women. Fertil. Steril. 1982; 38(4): 406-9.
- Дедов И.И., Мельниченко Г.А., ред. Эндокринология. Национальное руководство. М.: ГЭОТАР- Медиа; 2013. 752с. [Dedov I.I., Melnichenko G.A., eds. Endocrinology. Natsionalnoe guideline. Moscow: GEOTAR- Media; 2013. 752p. (in Russian)]
- Романцова Т.И. Основные принципы регуляции энергетического баланса. Consilium medicum. 2014; 16(4): 98-102. [Romantsova T.I. The basic principles of the regulation of energy balance. Consilium medicum. 2014; 16(4): 98-102. (in Russian)]
- Аметов А.С. Эффективное лечение ожирения - путь борьбы с эпидемией diabetus mellipidus. Медицинский совет. 2013; 2(2): 78-84. [Ametov A.S. Effective treatment of obesity - a way to fight the epidemic diabetus mellipidus. Meditsinskiy sovet. 2013; 2(2): 78-84. (in Russian)]
- Трошина Е.А., Мазурина Н.В., Галиева М.О. Создание стратегий лечения ожирения и коморбидных заболеваний на основе наблюдательных программ: промежуточные результаты Всероссийской наблюдательной программы «ПримаВера». Альманах клинической медицины. 2015; Спецвыпуск 1: 95-101. [Troshina E.A., Mazurina N.V., Galieva M.O. Create strategies for treating obesity and comorbid disorders on the basis of observational programs: interim results of All-Russian observation program «Primavera». Almanah klinicheskoy meditsinyi. 2015; Spetsvyipusk 1: 95-101. (in Russian)]
- Манушарова Р.А., Черкезова Э.И. Комплексная терапия ожирения сибутрамином и орлистатом. Медицинский совет. 2008; 9-10: 66-9. [Manusharova R.A., Cherkezova E.I. Combined therapy of obesity with sibutramine and orlistat. Meditsinskiy sovet. 2008; 9-10: 66-9. (in Russian)]
- Lindholm A., Bixo M., Bjorn I., Wolner-Hanssen P., Eliasson M., Larsson A. et al. Effect of sibutramine on weight reduction in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Fertil. Steril. 2008; 89(5): 1221-8.
- Бутрова С.А. Метаболический синдром: патогенез, клиника, диагностика и подходы к лечению. Русский медицинский журнал. 2001; 2: 56-60. [Butrova S.A. Metabolic syndrome: pathogenesis, clinical features, diagnosis and treatment approaches. Russian Medical Journal. 2001; 2: 56-60. (in Russian)]
- McNulty S.J., Ur E., Williams G.; Multicenter Sibutramine Study Group. A randomized trial of sibutramine in the management of obese type 2 diabetic patients treated with metformin. Diabetes Care. 2003; 26(1): 125-31.
- Никишова Т.В. Этиология, патогенез, лечение ожирения. Практическая медицина. Акушерство. Гинекология. Эндокринология. 2015; 1: 147-50. [Nikishova T.V. Etiology, pathogenesis, treatment of obesity. Prakticheskaya meditsina. Akusherstvo. Ginekologiya. Endokrinologiya. 2015; 1: 147-50. (in Russian)]
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