Current assisted reproductive technologies and child and adult health programming


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Abstract

The periconceptional period in human development is defined as a highly narrow window of time, which covers the preconceptional period and the period of conception to embryo implantation, during which actions on the mother and impregnated ovum are able to affect the further growth and physiological characteristics of progeny. Investigations using human and animal models have shown that in vitro embryo culturing conditions and actions on gametes and embryos may considerably influence an individual’s health in further life. Epigenetic DNA exposures and chromatin organization processes are the most likely mechanisms for the influence of environmental factors and assisted reproductive technologies on further development and phenotype. The long-term effects of modifying periimplantation development conditions on the progeny’s further health are discussed.

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About the authors

N. V Bashmakova

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; Ural State Medical University, Ministry of Health of Russia

Email: dr@niiomm.ru
MD, ScD, Professor, Director

P. B Tsyvyan

Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia; Ural State Medical University, Ministry of Health of Russia; Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences

Email: pavel.tsyvian@gmail.com
MD, ScD, Professor, Head of Normal Physiology Department

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