Impact of iron-deficiency anemia on pregnancy outcomes


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Many health features in pregnant women affect the status of a fetus and then a newborn infant. Iron-deficiency anemia is the most commonly detected condition during pregnancy, which not only worsens quality of life for a woman, but can also negatively affect the fetal status. The literature describes poor iron deficiency-related pregnancy outcomes, a number of which are validly confirmed. The timely detection of iron-deficiency anemia and its effective therapy allow the prevention of complications, thus improving the outcome of pregnancy.

Full Text

Restricted Access

About the authors

M. A Vinogradova

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: mary-grape@ya.ru
MD, senior research associate in transfusion department

T. A Fedorova

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: t_fyodorova@oparina4.ru
MD, PhD, Chief of transfusion department

O. V Rogachevsky

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_rogachevskiy@oparina4.ru
MD, PhD, the leading scientific researcher in transfusion department

References

  1. Stevens G., Finueane М., De-Regil L., Paeiorek C., Flaxman S., Branca F. et al. Global, regional, and national trends in total and severe anaemia prevalence in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob. Health. 2013; 1(1): e16-25.
  2. Milman N., Bergholt T., Byg K.E., Eriksen L., Graudal N. Iron status and iron balance during pregnancy: a critical reappraisal of iron supplementation. Acta Obstet. Gynecol. Scand 1999; 78(9): 749-57.
  3. Werner E.J., Stoekman J.A., 3rd. Red cell disturbances in the feto-maternal unit. Semin. Perinatol. 1983; 7(3): 139-58.
  4. Alien L.H. Anemia and iron deficiency: effects on pregnancy outcome. Am. J. Clin. Nutr. 2000; 71(5, Suppl.): 1280S-4S.
  5. Sue Pavord, Beverley Hunt, eds. The obstetric hematology manual. Cambridge University Press; 2010: 13-27.
  6. Stoltzfus R., Mullany L., Blaek R. Iron deficiency anemia. In: Ezzati M., Lopez A., Rodgers A., Murray C., eds. Comparative quantification of health risks. Global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization; 2004; vol.1: 163-209.
  7. Scholl Т.O., Hediger M.L., Fischer R.L., Shearer J.W. Anemia vs iron deficiency: increased risk of preterm delivery in a prospective study. Am. J. Clin. Nutr. 1992; 55(5): 985-8.
  8. Xiong X., Buekens P., Alexander S., Demianczuk N., Wollasi E. Anemia during pregnancy and birth outcome: a meta-analysis. Am. J. Perinatol. 2000; 17(3): 137-46.
  9. Pena-Rosas J.P., De-Regil L.M., Dowswell T., Viieri F.E. Daily oral iron supplementation during pregnancy. Cochrane Database Syst. Rev. 2012; (12): CD004736.
  10. Imdad A., Bhuiia Z.A. Routine iron/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes. Paediatr. Perinat. Epidemiol. 2012; 26(Suppl. 1): 168-77.
  11. Harris E.D. New insights into placental iron transport. Nutr. Rev. 1992; 50(11): 329-31.
  12. Chi I.C., Agoesiina T., Harbin J. Maternal mortality at twelve teaching hospitals in Indonesia-an epidemiologic analysis. Int. J. Gynaecol. Obstet. 1981;19(4): 259-66.
  13. Arnold D.L., Williams M.A., Miller R.S., Qiu C., Sorensen Т.К. Iron deficiency anemia, cigarette smoking and risk of abruptio placentae. J. Obstet. Gynaecol. Res. 2009; 35(3): 446-52.
  14. Allen L.H. Biological mechanisms that might underlie iron’s effects on fetal growth and preterm birth. J. Nutr. 2001; 131(2): 581S-9S.
  15. Rasmussen K. Is there a causal relationship between iron deficiency or iron-deficiency anemia and weight at birth, length of gestation and perinatal mortality? J. Nutr. 2001; 131(2): 590S-603S.
  16. Steer P.J. Maternal hemoglobin concentration and birth weight. Am. J. Clin. Nutr. 2000; 71(5, Suppl.): 1285S-7S.
  17. Scholl Т. O., Hediger M.L. Anemia and iron-deficiency anemia: compilation of data on pregnancy outcome. Am. J. Clin. Nutr. 1994; 59(2, Suppl.): 492S-500S.
  18. Singla P.N., Tyagi M., Kumar A., Dash D., Shankar R. Fetal growth in maternal anaemia. J. Trop. Pediatr. 1997; 43(2): 89-92.
  19. Barker D.J., Bull A.R., Osmond C., Simmonds S.J. Fetal and placental size and risk of hypertension in adult life. Br. Med. J. 1990; 301(6746): 259-62.
  20. Godfrey k.M., Redman C.W., Barker D.J., Osmond C. The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Br. J. Obstet. Gynaecol. 1991; 98(9): 886-91.
  21. Haider B.A., Olofin I., Wang M., Spiegelman D., Ezzati M., Fawzi W.W.; Nutrition Impact Model Study Group (anaemia). Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. Br. Med. J. 2013; 346: f3443.
  22. Scholl Т.O. Iron status during pregnancy: setting the stage for mother and infant. Am. J. Clin. Nutr. 2005; 81(5, Suppl.): 1218S-22S.
  23. Rasmussen S., Oian P. First- and second-trimester hemoglobin levels. Relation to birth weight and gestational age. Acta Obstet. Gynecol. Scand. 1993; 72(4): 246-51.
  24. Foresi J.C., Masse J., Mouiquin J.M. Maternal hematocrit and albumin as predictors of intrauterine growth retardation and preterm delivery. Clin. Biochem. 1996; 29(6): 563-6.
  25. Murphy J.F., O’Riordan J., Newcombe R.G., Coles E.C., Pearson J.F. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet. 1986; 1(8488): 992-5.
  26. Scholl Т.O., Reilly T. Anemia, iron and pregnancy outcome. J. Nutr. 2000; 130(2, Suppl.): 443S-7S.
  27. Scanlon K.S., Yip R., Schieve L.A., Cogswell M.E. High and low hemoglobin levels during pregnancy: differential risks for preterm birth and small for gestational age. Obstet. Gynecol. 2000; 96(5, Pt1): 741-8.
  28. Institute of Medicine, Food and Nutrition Board. Iron deficiency anemia: guidelines for prevention, detection and management among U.S. children and women of childbearing age. Washington, DC: National Academy Press; 1993.
  29. de Alarcón Pedro A., Werner Eric, Christensen Roberi D., eds. Neonatal hematology: pathogenesis, diagnosis, and management of hematologic problems. 2nd ed. Cambridge: Cambridge University Press; 2013. 428p.
  30. Choi J.W., Kim C.S., Pai S.H. Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. Acta Paediatr. 2000; 89(6): 675-9.
  31. Colomer J., Colomer C., Gutierrez D., Jubert A., Nolasco A., Donat J. et al. Anaemia during pregnancy as a risk factor for infant iron deficiency: report from the Valencia Infant Anaemia Cohort (VIAC) study. Paediatr. Perinat. Epidemiol. 1990; 4(2): 196-204.
  32. Barion D.P., Joy M.T., Lappin T.R., Afrasiabi M., Morel J.G., O’Riordan J. et al. Maternal erythropoietin in singleton pregnancies: a randomized trial on the effect of oral hematinic supplementation. Am. J. Obstet. Gynecol. 1994; 170(3): 896-901.
  33. Preziosi P., Prual A., Galan P., Daouda H., Boureima H., Hercberg S. Effect of iron supplementation on the iron status of pregnant women: consequences for newborns. Am. J. Clin. Nutr. 1997; 66(5): 1178-82.
  34. Perez E.M., Hendricks M.K., Beard J.L., Murray-Kolb L.E., Berg A., Tomlinson M. et al. Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. J. Nutr. 2005; 135(4): 850-5.
  35. Beard J.L. Why iron deficiency is important in infant development. J. Nutr. 2008; 138(12): 2534-6.
  36. Insel B.J., Schaefer C.A., McKeague I.W., Susser E.S., Brown A.S. Maternal iron deficiency and the risk of schizophrenia in offspring. Arch. Gen. Psychiatry. 2008; 65(10): 1136-44.
  37. Chrisioph P., Schuller C., Siuder H., Irion O., De Tejada B.M., Surbek D. Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose. J. Perinat. Med. 2012; 40(5): 469-74.
  38. Pfenniger A., Schuller C., Chrisioph P., Surbek D. Safety and efficacy of high-dose intravenous iron carboxymaltose vs. iron sucrose for treatment of postpartum anemia. J. Perinat. Med. 2012; 40(4): 397-402.
  39. Reveiz L., Gyte G.M., Cuervo L.G., Casasbuenas A. Treatments for iron-deficiency anaemia in pregnancy. Cochrane Database Syst. Rev. 2011; (10): CD003094.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies