Effects of leptin and insulin on the production of gonadotropins in girls with abnormal uterine bleeding


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Objective. To study the associations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) with the basal levels of leptin and insulin in abnormal uterine bleeding (AUB) in female adolescents with different body weights. Subjects and methods. The study enrolled 146 female adolescents aged 11 to 18 years with AUB, including 58 adolescents with the physiological parameters growth and weight (Group 1), 57 overweight girls (Group 2), and 31 underweight adolescents (Group 3). The serum levels of LH, FSH, PRL, leptin, and insulin were measured. Results. Multiple regression analysis revealed the specific features of associations of gonadotropic hormones with leptin and insulin. Energy metabolic hormones were shown to have a selective effect on body mass index (BMI)-dependent gonadotropin production. Conclusion. Leptin and insulin play an important role in the pathogenesis of AUB in the pubertal period and have a significant BMI-dependent effect responsible for uterine bleeding on the production of pituitary hormones.

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作者简介

Victoria Dynnik

Institute of Child and Adolescent Health Care, National Academy of Medical Sciences of Ukraine

Email: viktorija-dynnik@yandex.ua. iozdp@iozdp.org.ua
MD, Scientific Secretary

Nikolai Shcherbina

Kharkov National Medical University, Ministry of Health of Ukraine

MD, Professor, Head of the Department of Obstetrics and Gynaecology № 1

Alexander Dynnik

Kharkov National Medical University, Ministry of Health of Ukraine

Email: dynunja@rambler.ru
graduate student of the Department of Obstetrics and Gynaecology № 1

参考

  1. Дедов И.И., Мельниченко Г.А., Бутрова С.А. Жировая ткань как эндокринный орган. Ожирение и метаболизм. 2006; 3(1): 7-13
  2. Дедов И.И., Мельниченко Г.А., Бутрова С.А., Савельева Л.В. Ожирение в подростковом возрасте: результаты российского эпидемиологического исследования. Терапевтический архив. 2007; 79(10): 28-31.
  3. Беляков Н.А., Мазуров В.И., ред. Ожирение. Руководство для врачей. СПб.: Издательский дом СПб МАПО; 2003. 520с.
  4. Мкртумян А.М. Ожирение - проблема XXI века. Пути решения. Русский медицинский журнал. 2005; 13(7): 448-51.
  5. Bray G. Complications of obesity. Ann. Intern. Med. 1985; 103(6, Pt2): 1052-62.
  6. Перова Н.В., Метельская В.А., Мамедов М.Н., Оганов Р.Г. Методы раннего выявления и коррекции метаболического синдрома. Профилактика заболеваний и укрепление здоровья. 2001; 1: 18-31.
  7. Byrnes S.E., Baur L.A., Bermingham M., Brock K., Steinbeck K. Leptin and total cholesterol are predictors of weight gain in pre-pubertal children. Int. J. Obes. Relat. Metab. Disord. 1999; 23(2): 146-50.
  8. Jéquier E. Leptin signaling, adiposity, and energy balance. Ann. N. Y. Acad. Sci. 2002; 967: 379-88.
  9. Magni P., Motta M., Martini L. Leptin: a possible link between food intake, energy expenditure, and reproductive function. Regul. Pept. 2000; 92(1-3): 51-6.
  10. Moschos S., Chan J.L., Mantzoros Chr.S. Leptin and reproduction. Fertil. Steril. 2002; 77(3): 433-44.
  11. Klein S. Medical management of obesity. Surg. Clin. North Am. 2001; 81(5): 1025-38.
  12. Matsumura K., Abe I., Tsuchihashi T., Fujishima M. Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000; 278(5): R1314-20.
  13. Ahima R.S., Flier J.S. Leptin. Annu. Rev. Physiol. 2000; 62: 413-37.
  14. Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Müller C., Carling D., Kahn B.B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinasе. Nature. 2002; 415(6869): 339-43.
  15. Cunningham M.J., Clifton D.K., Steiner R.A. Leptin’s actions on the reproductive axis: perspectives and mechanisms. Biol. Reprod. 1999; 60(2): 216- 22.
  16. Gomez J.M., Maravall F.J., Gomez N., Navarro M.A., Casamitjana R., Soler J. Interactions between serum leptin, the insulin-like growth factor-1 system, and age, sex, anthropometric and body composition variables in a healthy population randomly selected. Clin. Endocrinol.(Oxford). 2003; 58(2): 213-9.
  17. Mann D.R., Johnson A.K., Gimpel T., Castracane D. Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. J. Clin. Endocrinol. Metab. 2003; 88(7): 3339-45.
  18. Rutters F., Nieuwenhuizen A.G., Verhoef S.P.M., Lemmens S.G.T., Vogels N., Westerterp-Plantenga M.S. The relationship between leptin, gonadotropic hormones, and body composition during puberty in a Dutch children cohort. Eur. J. Endocrinol. 2009; 160(6): 973-8.
  19. Wong S.L., De Paoli A.M., Lee J.H., Mantzoros C.S. Leptin hormonal kinetics in the fed state: effects of adiposity, age, and gender on endogenous leptin production and clearance rates. J. Clin. Endocrinol. Metab. 2004; 89(6): 2672-7.
  20. Межлумян М.Р. Патогенетические звенья развития избыточной массы тела и ее воздействия на репродуктивную систему у девочек-подростков. Репродуктивное здоровье детей и подростков. 2008; 3: 41-65.
  21. Burcelin R., Thorens B., Glauser M., Gaillard R.C., Pralong F.P. Gonadotropin-releasing hormone secretion from hypothalamic neurons stimulation by insulin and potentiation by leptin. Endocrinology. 2003; 144(10): 4484-91.
  22. Овсянникова T.B., Демидова И.Ю., Глазкова О.И. Гонадотропная функция инсулина. Гиперандрогения и гиперинсулинемия. Проблемы репродукции. 1998; 4(6): 5-8.
  23. Sudi K.M., Gallistl S., Weinhandl G., Muntean W., Borkenstein M.H. Relationship between plasminogen activator inhibitor-1, leptin, and fat mass in obese children and adolescents. Metabolism. 2000; 49(7): 890-5.

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