Effects of leptin and insulin on the production of gonadotropins in girls with abnormal uterine bleeding
- Authors: Dynnik V.A.1, Shcherbina N.A.2, Dynnik A.A.2
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Affiliations:
- Institute of Child and Adolescent Health Care, National Academy of Medical Sciences of Ukraine
- Kharkov National Medical University, Ministry of Health of Ukraine
- Issue: No 10 (2015)
- Pages: 81-85
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247533
- ID: 247533
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Abstract
Objective. To study the associations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) with the basal levels of leptin and insulin in abnormal uterine bleeding (AUB) in female adolescents with different body weights. Subjects and methods. The study enrolled 146 female adolescents aged 11 to 18 years with AUB, including 58 adolescents with the physiological parameters growth and weight (Group 1), 57 overweight girls (Group 2), and 31 underweight adolescents (Group 3). The serum levels of LH, FSH, PRL, leptin, and insulin were measured. Results. Multiple regression analysis revealed the specific features of associations of gonadotropic hormones with leptin and insulin. Energy metabolic hormones were shown to have a selective effect on body mass index (BMI)-dependent gonadotropin production. Conclusion. Leptin and insulin play an important role in the pathogenesis of AUB in the pubertal period and have a significant BMI-dependent effect responsible for uterine bleeding on the production of pituitary hormones.
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About the authors
Victoria A. Dynnik
Institute of Child and Adolescent Health Care, National Academy of Medical Sciences of Ukraine
Email: viktorija-dynnik@yandex.ua. iozdp@iozdp.org.ua
MD, Scientific Secretary
Nikolai A. Shcherbina
Kharkov National Medical University, Ministry of Health of UkraineMD, Professor, Head of the Department of Obstetrics and Gynaecology № 1
Alexander A. Dynnik
Kharkov National Medical University, Ministry of Health of Ukraine
Email: dynunja@rambler.ru
graduate student of the Department of Obstetrics and Gynaecology № 1
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