COMPREHENSIVE APPROACH TO TREATING CERVICAL PRECANCEROUS DISEASES (HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESIONS) IN THE PRESENCE OF HPV


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Abstract

Objective. To investigate the efficacy of Isoprinosine in the combination therapy of cervical precancerous diseases in the presence of human papillomavirus (HPV) types 16 and 18 in combination with conization of the cervix uteri. Subjects and methods. Eighteen patients with morphologically verified high-grade squamous intraepithelial lesions and HPV 16/18 were examined. A control group consisted of 10 gynecologically and somatically healthy women whose mean age was 25.8+5.7years. Results. Post-treatment analysis of changes in T cell components indicated that Isoprinosine had a marked immunomodulatory effect. CD3, CD4, CD8, CD20, and IgG were responsible for a significant increase in the indicators versus the baseline values. The patients tolerated the used treatment without complications. Conclusion. The investigation conducted proves once again the need for combination treatment for cervical precancerous diseases. Timely adequate treatment will prevent malignant processes of the cervix uteri.

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About the authors

Yulia E Dobrokhotova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: pr.dobrohotova@mail.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology, Medical Faculty 117049, Russia, Moscow, Leninsky pr-t 8

M. G Venediktova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

MD, Associate Professor of the Department of Obstetrics and Gynecology, Medical Faculty Moscow 117997, Ostrovityanova str. 1, Russia

Igor I. Grishin

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: doctoraibolit@rambler.ru
Associate Professor of the Department of Obstetrics and Gynecology, Medical Faculty Moscow 117997, Ostrovityanova str. 1, Russia

A. N Sarantsev

City Clinical Hospital 40

PhD, Head of the 3rd Oncology Department Moscow 129301, Kasatkina str. 7, Russia

Ksenia V. Morozova

N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: morozovadk@mail.ru
post-graduate student of the Department of obstetrics and gynecology Moscow 117997, Ostrovityanova str. 1, Russia

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