Significance of detoxification system gene polymorphisms in preeclampsia


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Abstract

Objective. To give an update on a relationship between detoxification system gene polymorphisms and the development of preeclampsia. Materials and methods. The available literature sources published in Medline, Pubmed, and other databases, were sought. The authors found 68 sources on a relationship between detoxification gene polymorphisms and the development of preeclampsia, out of which 49 were included in this review. Results. The concept of the role of single nucleotide polymorphisms of the detoxification system in the development of oxidative stress in preeclampsia was set forth. The major detoxification system genes (GSTP1, GSTM1, GSTT1, GPX1, EPHX1, SOD-2, SOD-3, CYP1A1, MTHFR, and MTR) and their functions were given. The most significant gene polymorphisms were revealed in preeclampsia. The data found in the available literature on the relationship between the polymorphisms and the rate of preeclampsia, as well as on the placental expression of these genes in this disease were analyzed. Conclusion. The early diagnosis of preeclampsia has not been fully studied It is necessary to conduct further investigations in this area.

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About the authors

Natalia E. Kan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
PhD, MD, the head of the obstetric observation department

Lev A. Bednyagin

M.V. Lomonosov Moscow State University

Email: levbed@mail.ru
student of 2Faculty of Fundamental Medicine

Victor L. Tyutyunnik

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
PhD, MD, the head of the obstetric physiological department

Petimat A. Khovkhaeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: p_hovhaeva@oparina4.ru
the postgraduate student

Andrey E. Donnikov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
M.D., Ph.D., Senior Researcher of Molecular-Genetic Laboratory

Nataliya V. Dolgushina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

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