Prophylactic salpingectomy


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To study main strategies for prophylactic salpingectomy and its impact on ovarian reserve. Material and methods. The key words «salpingectomy» and “ovarian reserve» (or «FSH», or «AMH», or «AFC») were used to look for the literature in the Medline database. A total of 25 sources were analyzed. Twenty articles were selected. Results. The paper provides a scientific rationale for surgery at varying degrees of risk for serous ovarian cancer. It shows that there is a need for simultaneous salpingectomy in women during hysterectomy. The role of the technique in enhancing the efficiency of treatment for infertility is discussed. Conclusion. After salpingectomy, there is a secondary ovarian failure risk, the estrogen deficiency consequences of which may outweigh the benefit of the decreased incidence of ovarian cancer and the prevention of small pelvic inflammatory diseases. Unintended surgical aggression against small pelvic organs without direct damage to the gonads (salpingectomy) has a critical impact on ovarian reserve in patients with an initial decline in ovarian function.

Full Text

Restricted Access

About the authors

Ilya Alekseevich Petrov

Siberian State Medical University, Ministry of Health of Russia

Email: obgynsib@gmail.com
Candidate of Medicine, Assistant of the Department of Obstetrics and Gynecology

Olga Anatolyevna Tikhonovskaya

Siberian State Medical University, Ministry of Health of Russia

Email: tikhonovskaya20l2@mail.ru
Doctor of Medicine, Professor of the Department of Obstetrics and Gynecology

Alexandr Olegovich Okorokov

Siberian State Medical University, Ministry of Health of Russia

Email: okorokao@mail.ru
Candidate of Medicine, Assistant Professor of the Department of Obstetrics and Gynecology

Irina Igorevna Kupriyanova

Siberian State Medical University, Ministry of Health of Russia

Email: kuprianovaii@sibmail.com
Postgraduate of the Department of Histology, Embryology and Cytology

Aleksandra Sergeevna Fateeva

Siberian State Medical University, Ministry of Health of Russia

Email: fateeva.aleksandra@mail.ru
Postgraduate of the Department of Obstetrics and Gynecology

Marina Sergeevna Petrova

Siberian State Medical University, Ministry of Health of Russia

Email: marina.gin2011@mail.ru
Candidate of Medicine, Assistant Professor of the Department of Obstetrics and Gynecology

Sergey Valentinovich Logvinov

Siberian State Medical University, Ministry of Health of Russia

Email: S_Logvinov@mail.ru
Doctor of Medicine, Professor, Head of the Department of Histology, Embryology and Cytology

References

  1. Сухих Г.Т., Адамян Л.В. Состояние и перспективы репродуктивного здоровья населения России. В кн.: Кулаков В.И., Адамян Л.В., ред. Современные технологии в диагностике и лечении гинекологических заболеваний. М.: Пантори; 2007: 5-19. [Sukhikh G.T., Adamyan L.V. State and prospects of Russia’s population of reproductive health.In: Kulakov V.I., Adamyan L.V., ed. Modern technology in the diagnosis and treatment of gynecological diseases. Moscow: Pantori; 2007: 5-19. (in Russian)]
  2. Доброхотова Ю.Э., ред. Клинические лекции по акушерству и гинекологии. Руководство. Доброхотова Ю.Э., Бояр Е.А., Хейдар Л.А. и др. М.: ГЭОТАР-Медиа; 2009. 312с. [Dobrokhotova Yu.E., eds. Clinical lectures on obstetrics and gynecology. Guide. Dobrokhotova Yu.E., Boyar E.A., Heidar L.A. et al. Moscow: GEOTAR Media.; 2009. 312p. (in Russian)]
  3. Стрижаков А.Н., Давыдов А.И., Мусаев Р.Д. Овариальный резерв у больных с эндометриоидными кистами яичников после лапароскопических операций с использованием высоких хирургических энергий. В кн.: Сухих Г.Т., Адамян Л.В., ред. Новые технологии в диагностике и лечении гинекологических заболеваний. М.; 2011: 101-2. [Strizhakov A.N. Davydov A.I., Musayev R.D. Ovarian reserve in patients with endometrioid ovarian cysts after laparoscopic surgery using high energies. In: Sukhikh G.T., Adamyan L.V., ed. New technologies in diagnostics and treatment of gynecological diseases. Moscow; 2011: 101-2. (in Russian)]
  4. Кадесникова Ю.А., Тихоновская О.А., Петров И.А., Окороков А.О., Логвинов С.В. Состояние овариального резерва пациенток с функциональными кистами яичников после лапароскопической цистэктомии. Сибирский медицинский журнал. 2010; 25(4): 83-5. [Kadesnikova Yu.A., Tihonovskaya O.A., Petrov I.A., Okorokov A.O., Logvinov S.V. Status ovarian reserve patients with functional ovarian cysts after laparoscopic cystectomy. Sibirskiy meditsinskiy zhurnal. 2010; 25(4): 83-5. (in Russian)]
  5. Iwase A., Nakamura T., Nakahara T., Goto M., Kikkawa F. Assessment of ovarian reserve using anti-Müllerian hormone levels in benign gynecologic conditions and surgical interventions: a systematic narrative review. Reprod. Biol. Endocrinol. 2014; 12: 125.
  6. Mukhopadhaya N., Manyonda I.T. The hysterectomy story in the United Kingdom. J. Midlife Health. 2013; 4(1): 40-1.
  7. Фатеева А.С., Петров И.А., Тихоновская О.А., Логвинов С.В. Морфофункциональное состояние яичников после гистерэктомии. Бюллетень сибирской медицины. 2014; 13(1): 145-52. [Fateeva A.S., Petrov I.A., Tihonovskaya O.A., Logvinov S.V. Morphofunctional state of the ovaries after hysterectomy. Byulleten sibirskoy meditsinyi. 2014; 13(1): 145-52. (in Russian)]
  8. Schenberg T., Mitchell G. Prophylactic bilateral salpingectomy as a prevention strategy in women at high-risk of ovarian cancer: a mini-review. Front. Oncol. 2014; 4: 21.
  9. Vorwergk J., Radosa M.P., Nicolaus K., Baus N., Jimenez Cruz J., Rengsberger M. et al. Prophylactic bilateral salpingectomy (PBS) to reduce ovarian cancer risk incorporated in standard premenopausal hysterectomy: complications and re-operation rate. J. Cancer Res. Clin. Oncol. 2014; 140(5): 859-65.
  10. Chan C.C., Ng E.H., Ho P.C. Ovarian changes after abdominal hysterectomy for benign conditions. J. Soc. Gynecol. Investig. 2005; 12(1): 54-7.
  11. Nahäs E.A., Pontes A., Traiman P., Nahás-Neto J., Dalben I., De Luca L. Inhibin B and ovarian function after total abdominal hysterectomy in women of reproductive age. Gynecol. Endocrinol. 2003; 17(2): 125-31.
  12. Vuorento T., Mäenpää J., Huhtaniemi I. Follow-up of ovarian endocrine function in premenopausal women after hysterectomy by daily measurements of salivary progesterone. Clin. Endocrinol. (Oxf). 1992; 36(5): 505-10.
  13. Chalmers C., Lindsay M., Usher D., Warner P., Evans D., Ferguson M. Hysterectomy and ovarian function: levels of follicle stimulating hormone and incidence of menopausal symptoms are not affected by hysterectomy in women under age 45 years. Climacteric. 2002; 5(4): 366-73.
  14. Ciarmela P., Islam M.S., Reis F.M., Gray P.C., Bloise E., Petraglia F. et al. Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications. Hum. Reprod. Update. 2011; 17(6): 772-90.
  15. Nahäs E.A., Pontes A., Nahas-Neto J., Borges V.T., Dias R., Traiman P. Effect of total abdominal hysterectomy on ovarian blood supply in women of reproductive age. J. Ultrasound Med. 2005; 24(2): 169-74.
  16. Bhattacharya S., Mollison J., Pinion S., Parkin D.E., Abramovich D.R., Terry P. et al. A comparison of bladder and ovarian function two years following hysterectomy or endometrial ablation. Br. J. Obstet. Gynaecol. 1996; 103(9): 898-903.
  17. Morelli M., Venturella R., Mocciaro R., Di Cello A., Rania E., Lico D. et al. Prophylactic salpingectomy in premenopausal low-risk women for ovarian cancer: primum non nocere. Gynecol. Oncol. 2013; 129(3): 448-51.
  18. Colgan T.J., Murphy J., Cole D.E., Narod S., Rosen B. Occult carcinoma in prophylactic oophorectomy specimens: prevalence and association with BRCA germline mutation status. Am. J. Surg. Pathol. 2001; 25(10): 1283-9.
  19. Piek J.M., van Diest P.J., Zweemer R.P., Jansen J.W., Poort-Keesom R.J., Menko F.H. et al. Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J. Pathol. 2001; 195(4): 451-6.
  20. Crum C.P., Drapkin R., Kindelberger D., Medeiros F., Miron A., Lee Y. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin. Med. Res. 2007; 5(1): 35-44.
  21. Salvador S., Gilks B., Köbel M., Huntsman D., Rosen B., Miller D. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int. J. Gynecol. Cancer. 2009; 19(1): 58-64.
  22. Leblanc E., Narducci F., Farre I., Peyrat J.P., Taieb S., Adenis C. et al. Radical fimbriectomy: a reasonable temporary risk-reducing surgery for selected women with a germ line mutation of BRCA 1 or 2 genes? Rationale and preliminary development. Gynecol. Oncol. 2011; 121(3): 472-6.
  23. Greene M.H., Mai P.L., Schwartz P.E. Does bilateral salpingectomy with ovarian retention warrant consideration as a temporary bridge to risk-reducing bilateral oophorectomy in BRCA1/2 mutation carriers? Am. J. Obstet. Gynecol. 2011; 204(1): 19. e1-6.
  24. Repasy I., Lendvai V., Koppan A., Bodis J., Koppan M. Effect of the removal of the Fallopian tube during hysterectomy on ovarian survival: the orphan ovary syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009; 144(1): 64-7.
  25. Morse A.N., Schroeder C.B., Magrina J.F., Webb M.J., Wollan P.C., Yawn B.P. The risk of hydrosalpinx formation and adnexectomy following tubal ligation and subsequent hysterectomy: a historical cohort study. Am. J. Obstet. Gynecol. 2006; 194(5): 1273-6.
  26. Ghezzi F., Cromi A., Siesto G., Bergamini V., Zefiro F., Bolis P. Infectious morbidity after total laparoscopic hysterectomy: does concomitant salpingectomy make a difference? BJOG. 2009; 116(4): 589-93.
  27. Ouldamer L., Caille A., Body G. Fallopian tube prolapse after hysterectomy: a systematic review. PLoS One. 2013; 8(10): e76543.
  28. Parihar M., Mirge A., Hasabe R. Hydrosalpinx functional surgery or salpingectomy? The importance of hydrosalpinx fluid in assisted reproductive technologies. J. Gynecol. Endosc. Surg. 2009; 1(1): 12-6.
  29. Dechaud H., Hedon B. What effect does hydrosalpinx have on assisted reproduction? The role of salpingectomy remains controversial. Hum. Reprod. 2000; 15(2): 234-5.
  30. Stranded A., Lindhard A., Waldenström U., Thorburn J., Janson P.O., Hamberger L. Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF. Hum. Reprod. 1999; 14(11): 2762-9.
  31. Johnson N.P., van Voorst S., Sowter M.C., Strandell A., Mol B.W. Surgical treatment for tubal disease in women due to undergo in vitro fertilisation. Cochrane Database Syst. Rev. 2010; (1): CD002125.
  32. Bontis J.N., Theodoridis T.D. Laparoscopic management of hydrosalpinx. Ann. N.Y. Acad. Sci. 2006; 1092: 199-210.
  33. Strandell A., Lindhard A. Why does hydrosalpinx reduce fertility? The importance of hydrosalpinx fluid. Hum. Reprod. 2002; 17(5): 1141-5.
  34. Chanelles O., Ducarme G., Sifer C., Hugues J.N., Touboul C., Poncelet C. Hydrosalpinx and infertility: what about conservative surgical management? Eur. J. Obstet. Gynecol. Reprod. Biol. 2011; 159(1): 122-6.
  35. Atilgan R., Kuloglu T., Boztosun A., Orak U., Baspinar M., Can B. et al. Investigation of the effects of unilateral total salpingectomy on ovarian proliferating cell nuclear antigen and follicular reserve: experimental study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2015; 188(1): 56-60.
  36. Gelbaya T.A., Nardo L.G., Fitzgerald C.T., Horne G., Brison D.R., Lieberman B.A. Ovarian response to gonadotropins after laparoscopic salpingectomy or the division of fallopian tubes for hydrosalpinges. Fertil. Steril. 2006; 85(5): 1464-8.
  37. Grynnerup A.G., Lindhard A., Sørensen S. Anti-Müllerian hormone levels in salpingectomized compared with nonsalpingectomized women with tubal factor infertility and women with unexplained infertility. Acta Obstet. Gynecol. Scand. 2013; 92(11): 1297-303.
  38. Nakagawa K., Ohgi S., Nakashima A., Horikawa T., Irahara M., Saito H. Laparoscopic proximal tubal division can preserve ovarian reserve for infertility patients with hydrosalpinges. J. Obstet. Gynaecol. Res. 2008; 34(6): 1037-42.
  39. Sezik M., Ozkaya O., Demir F., Sezik H.T., Kaya H. Total salpingectomy during abdominal hysterectomy: effects on ovarian reserve and ovarian stromal blood flow. J. Obstet. Gynaecol. Res. 2007; 33(6): 863-9.
  40. Ulug P., Oner G. Evaluation of the effects of single or multiple dose methotrexate administration, salpingectomy on ovarian reserve of rat with the measurement of anti-Müllerian hormone (AMH) levels and histological analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 2014; 181: 205-9.
  41. Ye X.P., Yang Y.Z., Sun X.X. A retrospective analysis of the effect of salpingectomy on serum anti-Müllerian hormone level and ovarian reserve. Am. J. Obstet. Gynecol. 2015; 212(1): 53. e1-10.
  42. Matorras R., Rabanal A., Prieto B., Diez S., Brouard I., Mendoza R. et al. Hysteroscopic hydrosalpinx occlusion with Essure device in IVF patients when salpingectomy or laparoscopy is contraindicated. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 169(1): 54-9.
  43. Findley A.D., Siedhoff M.T., Hobbs K.A., Steege J.F., Carey E.T., McCall C.A. et al. Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial. Fertil. Steril. 2013; 100(6): 1704-8.
  44. Hill M.J., Cooper J.C., Levy G., Alford C., Richter K.S., DeCherney A.H. et al. Ovarian reserve and subsequent assisted reproduction outcomes after methotrexate therapy for ectopic pregnancy or pregnancy of unknown location. Fertil. Steril. 2014; 101(2): 413-9.
  45. Uyar I., Yucel O.U., Gezer C., Gulhan I., Karis B., Hanhan H.M. et al. Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy. Fertil. Steril. 2013; 100(5): 1310-3.
  46. Wiser A., Gilbert A., Nahum R., Orvieto R., Haas J., Hourvitz A. et al. Effects of treatment of ectopic pregnancy with methotrexate or salpingectomy in the subsequent IVF cycle. Reprod. Biomed. Online. 2013; 26(5): 449-53.
  47. Xi W., Gong F., Tang Y., Zhang H., Lu G. Ovarian response to gonadotropins after laparoscopic salpingectomy for ectopic pregnancy. Int. J. Gynaecol. Obstet. 2012; 116(2): 93-6.
  48. Yi Q.H., Ling S.R., Chen K.M., He W.R., Li L., Yi C.J. Evaluation of the clinical value of simultaneous hysterectomy and bilateral salpingectomy in perimenopausal women. Zhonghua Fu Chan Ke Za Zhi. 2012; 47(2): 110-4.
  49. Meng X.H., Zhu Y.M. Effect of salpingectomy on ovarian function. Zhejiang Da XueXue BaoYiXue Ban. 2006; 35(5): 555-9.
  50. Ni L., Sadiq S., Mao Y., Cui Y., Wang W., Liu J. Influence of various tubal surgeries to serum antimullerian hormone level and outcome of the subsequent IVF-ET treatment. Gynecol. Endocrinol. 2013; 29(4): 345-9.

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies