ROLE OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS IN RECURRENT MISCARRIAGE


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Abstract

Objective. To carry out a systematic analysis of the data available in the modern literature on the role of major histocompatibility complex antigens in recurrent miscarriage, preterm delivery, fetal growth retardation, and preeclampsia. Subject and methods. The review included the data of foreign and Russian articles given in Pubmed on this topic and published in the past 15 years. Results. This review sets forth the present-day idea on the contribution of the marital HLA system (killer cell immunoglobulin-like receptors (KIRs), HLA-C antigens, HLA compatibility, and anti-HLA antibodies) to recurrent miscarriage, and other obstetric complications (preterm delivery, fetal growth retardation, and preeclampsia) associated with inadequate placentation. Conclusion. To understand the role of the HLA system during successful pregnancy and its complications, there is a need for further investigations, including a study of associations between recurrent miscarriage and specific maternal alleles, coincidences in HLA alleles in married couples, as well as for analysis of gene polymorphisms and a molecular interaction between KIRs and HLA-C molecules.

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About the authors

Olga V. Khoroshkeeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: khoroshkeeva.olga@gmail.com
Doctor of the Department of Pregnancy Loss Prevention and Therapy Moscow 117997, Ac. Oparina str. 4, Russia

Nana K. Tetruashvili

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy Moscow 117997, Ac. Oparina str. 4, Russia

Olga V. Bourmenska

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bourmenska@mail.ru
Ph.D., researcher of molecular-genetical laboratory Moscow 117997, Ac. Oparina str. 4, Russia

Anna A. Agadjanova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, leading researcher of the Department of Pregnancy Loss Prevention and Therapy Moscow 117997, Ac. Oparina str. 4, Russia

Dmitrii Y. Trophimov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_trofimov@oparina4.ru
Ph.D. in medical sciences, Head of Laboratory of molecular genetic methods Moscow 117997, Ac. Oparina str. 4, Russia

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