Experience with oxytocin receptor antagonist for incipient preterm labor


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Abstract

Objective. To present the results of analyzing 40 cases of use of the oxytocin receptor antagonist atosiban in incipient preterm labor. Material and methods. A group included 40 pregnant women with incipient preterm labor at 24-33 weeks’ gestation. Results. Pregnancy could be prolonged by a minimum of 7 days in 97.5% of the pregnant women with incipient preterm labor, which could perform a full prevention cycle for fetal respiratory distress syndrome. Following 48 hours, one half (21/40) of the women needed additional tocolysis using drugs from other groups. 90% of the women could prolong their pregnancy to full-term.

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About the authors

Ildar F. Fatkullin

Kazan State Medical University

MD, Professor, Head of the Obstetrics and Gynecology Department Two

Farid I. Fatkullin

Kazan State Medical University; City Clinical Hospital Seven

PhD, assistant professor of Obstetrics and Gynecology Department Two; head of the Department of Pregnancy Pathology

Adel A. Munavirova

Kazan State Medical University

intern of the Department of Obstetrics and Gynecology Department Two

Laysan H. Islamova

Kazan State Medical University

PhD, Assistant of the Obstetrics and Gynecology Department Two

Arthur R. Akhmetgaliev

Kazan State Medical University

graduate student of the Obstetrics and Gynecology Department Two

Alsu T. Shaikhetdinova

City Clinical Hospital Seven

doctor in the Department of Pregnancy Pathology

References

  1. Радзинский В.Е., Еремичев Р.Ю. Острый токолиз при преждевременных родах. Доказательства и перспективы. Российский вестник акушера-гинеколога. 2014; 14(6): 24-6. [Radzinskiy V.E., Eremichev R.Yu. Acute tocolysis in preterm labor. Evidence and prospects. Rossiyskiy vestnik akushera-ginekologa. 2014; 14(6): 24-6. (in Russian)]
  2. Савельева Г.М., Шалина Р.И., Спиридонов Д.С., Астраханцева М.М. Угроза преждевременных родов. Диагностика и лечение. Доктор.Ру. 2014; 12: 30-3. [Saveleva G.M., Shalina R.I., Spiridonov D.S., Astrahantseva M.M. The threat of premature birth. Diagnosis and treatment. Doktor.Ru. 2014; 12: 30-3. (in Russian)]
  3. Сухих Г.Т., Серов В.Н., Адамян Л.В., Филиппов О.С., Баев О.Р., Клименченко Н.И., Тетруашвили Н.К., Тютюнник В.Л., Ходжаева З.С., Холин А.М. Преждевременные роды. Клинические рекомендации. М.: ФГБУ «Научный Центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Министерства здравоохранения Российской Федерации; 2014: 26. [Suhih G.T., Serov V.N., Adamyan L.V., Filippov O.S., Baev O.R., Klimenchenko N.I., Tetruashvili N.K., Tyutyunnik V.L., Hodzhaeva Z.S., Holin A.M. Premature birth. Clinical guidelines. Moscow: Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia; 2014: 26. (in Russian)]
  4. Guinn D.A. Book review. Preterm labour: Managing risk in clinical practice. Edited by Jane Norman and Ian Greer. 417 p. N. Engl. J. Med. 2006; 355(7): 742. doi: 10.1056/NEJMbkrev39689.
  5. Roberts D., Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst. Rev. 2006; (3): CD004454.
  6. Di Renzo G.C., Roura L.C. Guidelines for the management of spontaneous preterm labor. J. Perinat. Med. 2006; 34(5): 359-66.
  7. Радзинский В.Е., Галина Т.В., Кирбасова Н.П., Гондаренко А. С. Преждевременные роды: есть ли перспективы? Акушерство и гине кология. 2015; 2: 99-103. [Radzinskiy V.E., Galina T.V., Kirbasova N.P., Gondarenko A.S. Radzinsky V.E., Galina T.V., Kirbasova N.P., Gondarenko A.S. Premature delivery: Are there promises? Akusherstvo i ginekologiya/Obstetrics and gynecology. 2015; 2: 99-103. (in Russian)]
  8. Haas D.M., Caldwell D.M., Kirkpatrick P., McIntosh J.J., Welton N.J. Tocolytic therapy for preterm delivery: systematic review and network meta-analysis. BMJ. 2012; 345: e6226.
  9. Romero R., Sibai B.M., Sanchez-Ramos L., Valenzuela G.J., Veille J.C., Tabor B. et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am. J. Obstet. Gynecol. 2000; 182(5): 1173-83.
  10. Wex J., Abou-Setta A.M., Clerici G., Di Renzo G.C. Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011; 157(2): 128-35.
  11. Плавинский С.Л., Шабалкин П.И. Клинико-экономическая оценка применения лекарственного препарата атозибан при угрозе преждевременных родов. Медицина. 2014; 2(2): 1-12. [Plavinskiy S.L., Shabalkin P.I. Clinical and economic evaluation of the use of the drug atosiban with the threat of premature birth. Meditsina. 2014; 2(2): 1-12. (in Russian)]
  12. Курцер М.А., Кутакова Ю.Ю., Черепнина А.Л., Борец М.В., Курбатская О.Н. Опыт применения трактоцила (атозибан) при лечении беременных с угрозой преждевременных родов. Российский вестник акушера-гинеколога. 2014; 14(3): 47-9. [Kurtser M.A., Kutakova Yu.Yu., Cherepnina A.L., Borets M.V., Kurbatskaya O.N. Experience with traktotsila (atosiban) in the treatment of pregnant women with threatened preterm labor. Rossiyskiy vestnik akushera-ginekologa. 2014; 14(3): 47-9. (in Russian)]
  13. Курцер М.А., Кутакова Ю.Ю., Черепнина А.Л., Борец М.В., Курбатская О.Н. Опыт применения атозибана при угрозе преждевременных родов. Эффективная фармакотерапия. 2014; 32: 40-3. [Kurtser M.A., Kutakova Yu.Yu., Cherepnina A.L., Borets M.V., Kurbatskaya O.N. Experience in the use of atosiban with the threat of premature birth. Effektivnaya farmakoterapiya. 2014; 32: 40-3. (in Russian)]
  14. Баев О.Р., Козлова О.А., Тысячный О.В., Усова Е.А. Применение блока-тора окситоциновых рецепторов - атозибана для торможения спонтанной родовой деятельности. Акушерство и гинекология. 2015; 1: 5-11. [Baev O.R., Kozlova O.A., Tysyachnyi O.V., Usova E.A. Use of the oxytocin receptor blocking agent atosiban to suppress spontaneous labor. Akusherstvo i ginekologiya/Obstetrics and gynecology. 2015; 1: 5-11. (in Russian)]

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