Cervical cancer screening: What is new in global practice?


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Abstract

Objective. To carry out a systematic review of the data available in the modern literature on the role of different molecular genetic markers for cervical carcinogenesis along with traditional cervical cancer screening methods. Material and methods. The review included the data of foreign and Russian articles published over the past 5 years and found in the Pubmed on this topic. Results. The paper describes main methods used for cervical cancer screening, as well as new epigenetic biomarkers that enable proper management tactics to be chosen in difficult clinical situations. Conclusion. Diagnostic biomarkers (WIFI gene methylation, the expression of mir-29b in the cervical epithelium, p16 and Ki67, etc.) play a pivotal role in interpreting the final diagnosis if there are controversial and ambiguous results of cytological examination and HPV testing, which emphasizes the need for their further investigation.

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About the authors

Gyuldana R. Bairamova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bayramova@mail.ru
MD, Head of Clinical Research and the outpatient department

Leonid Z. Faizullin

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l_faizullin@oparina4.ru
Ph.D., a leading researcher of the laboratory of molecular genetic methods

Anna I. Korolkova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: zaikinaai@icloud.com
II year intern

Andrei A. Poloznikov

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Email: andrey.poloznikov@gmail.com
PhD, Head of the Laboratory of Biochemistry and Enzymology

Vsevolod I. Kiselev

Peoples’ Friendship University of Russia

Email: vkis10@mail.ru
Doctor of Biological Sciences, professor, corresponding member of Russian Academy of Sciences, deputy director of the Institute of Biomedical Problems

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