Role of cyclooxygenases in the pathogenesis of genital endometriosis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To present an update on the role of cyclooxygenases (COX) in the development of endometriosis. Materials and methods. 182 literature sources on the role of COX-1 and COX-2 in the development of endometriosis in reproductive-aged women, which had been published in the Medline, Pubmed, and Scopus databases, were analyzed. 21 out of these sources were included in the present review. Results. The production of prostaglandins in the endometrial cells is one of the important pathogenetic components of genital endometriosis. Women with endometriosis were found to have specific features of the expression of COX-1 and COX-2 in the eutopic and ectopic endometrium, which correlate with the rate of cell proliferation and tissue growth and as a consequence with the progression of the disease. Conclusion. The role of cyclooxygenases in the development of endometriosis is of interest in that, on the basis of the knowledge obtained, one may plan the use of agents inhibiting the activity of cyclooxygenases (nonsteroidal anti-inflammatory drugs) to treat endometriosis as a pathogenetic treatment option. This issue has not been fully studied. There is a need for further investigations in this area.

Full Text

Restricted Access

About the authors

Yevgeny I. Samodelkin

Academician E.A. Wagner Perm State Medical University, Ministry of Helth of Russia

Email: sei-p@mail.ru
MD, Professor of Pathological Physiology

Polina V. Kosareva

Academician E.A. Wagner Perm State Medical University, Ministry of Helth of Russia

Email: perm-bagira@narod.ru
MD, main researcher of Department of morphological and pathophysiological studies CSRL, Head of the course of clinical laboratory diagnostics, an assistant professor of microbiology, virology with the course of clinical laboratory diagnostics

Ekaterina N. Tryastsina

The Badge of Honor Order Perm Territorial Clinical Hospital

Email: prh@permonline.ru
obstetrician-gynecologist

Larisa Yu. Nesterova

Ural Branch, Russian Academy of Sciences

Email: larisa.nesterova@bk.ru
PhD, Senior Researcher, Institute of Ecology and Genetics of Microorganisms

References

  1. Османова Ф.Т. Роль иммунологических факторов в патогенезе наружного генитального эндометриоза у женщин. Фундаментальные исследования. 2013; 9(1): 108-11. [Osmanova F.T. The role of immune factors in the pathogenesis of external genital endometriosis in women. Fundamentalnyie issledovaniya. 2013; 9(1): 108-11. (in Russian)]
  2. Пересада О.А. Эндометриоз: диагностические, клинические, онкологические и лечебные аспекты. Медицинские новости. 2009; 14: 15-28. [Peresada O.A. Endometriosis: diagnostic, clinical, and therapeutic aspects of cancer. Meditsinskie novosti. 2009; 14: 15-28. (in Russian)]
  3. Павлов Р.В., Кундохова М.С. Иммунологические критерии раннего прогнозирования рецидивов наружного генитального эндометриоза. Медицинский вестник Северного Кавказа. 2010; 21(1): 39-43. [Pavlov R.V., Kundohova M.S. Immunological criteria for early prediction of recurrence of external genital endometriosis. Meditsinskiy vestnik Severnogo Kavkaza. 2010; 21(1): 39-43. (in Russian)]
  4. Daftary G.S., Zheng Y., Tabbaa Z.M., Schoolmeester J.K., Gada R.P., Grzenda A.L. et al. Novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. PLoS One. 2013; 8(3): e60165.
  5. Попов А.В., Махмудова Г.М. Роль некоторых факторов перитонеальной жидкости в патогенезе эндометриоза. Российский вестник акушера-гинеколога. 2004; 2: 27-30. [Popov A.V., Mahmudova G.M. Role of peritoneal fluid of some factors in the pathogenesis of endometriosis. Rossiyskiy vestnik akushera- ginekologa. 2004; 2: 27-30. (in Russian)]
  6. Савельева Г.М., Соломатина А.А., Михалева Л.М., Пашкова А.В., Воробьева Н.Н. Еще раз о терминологии эндометриоидных образований яичников. Акушерство и гинекология. 2005; 6: 33-7. [Saveleva G.M., Solomatina A.A., Mihaleva L.M., Pashkova A.V., Vorobeva N.N. Once again on the terminology of endometrioid ovarian formations. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2005; 6: 33-7. (in Russian)]
  7. Olovsson M. Immunological aspects of endometriosis: an update. Am. J. Reprod. Immunol. 2011; 66(Suppl. 1): 101-4.
  8. Gao J., Niwa K., Sun W., Takemura M., Lian Z., Onogi K. et al. Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells. Cancer Sci. 2004; 95(11): 901-7.
  9. Xia H.H.X., Zhang S.T., Lam S.K., Lin M.C.M., Kung H.F., Wong B.C.Y. Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs. Carcinogenesis. 2005; 26(1): 11-5.
  10. Chen R.H., Tian Y.J. Enhanced anti-tumor efficacy of aspirin combined with triptolide in cervical cancer cells. Asian Pac. J. Cancer Prev. 2013; 14(5): 3041-4.
  11. Valle B.L., D'Souza T., Becker K.G., Wood W.H., Zhang Y., Wersto R.P. et al. Non-Steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells. PloS One. 2013; 8(4): e61836.
  12. Tosetti F., Ferrari N., De Flora S., Albini A. Angioprevention: angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J. 2002; 16(1): 2-14.
  13. Ломакин Н.В., Груздев А.К. Ингибиторы циклооксигеназы и антитромбоцитарный эффект ацетилсалициловой кислоты. Селективный подход к нестероидным противовоспалительным средствам в кардиологической практике. Кардиология. 2011; 51(7): 47-52. [Lomakin N.V., Gruzdev A.K. Cyclooxygenase inhibitors and the antiplatelet effect of acetylsalicylic acid. Selective approach to nonsteroidal anti-inflammatory agents in cardiology practice. Kardiologiya. 2011; 51(7): 47-52. (in Russian)]
  14. Nasir A., Boulware D., Kaiser H.E., Lancaster J.M., Coppola D., Smith P.V. et al. Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. In Vivo. 2007; 21(1): 35-43.
  15. Марченко Л.А., Ильина Л.М. Эндометриоз (современный взгляд на этиопатогенез и перспективы медикаментозной терапии). Русский медицинский журнал. 2010; 18(4): 171-5. [Marchenko L.A., Ilina L.M. Endometriosis (modern view on etiopathogenesis and prospects drug therapy). Russkiy meditsinskiy zhurnal. 2010; 18(4): 171-5. (in Russian)]
  16. Matsuzaki S., Canis M., Pouly J.L., Wattiez A., Okamura K., Mage G. Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. Fertil. Steril. 2004; 82(5): 1309-15.
  17. Chaudhry P., Asselin E. Resistance to chemotherapy and hormone therapy in endometrial cancer. Endocr. Relat. Cancer. 2009; 16(2): 363-80.
  18. Быков И.И., Микерова М.С., Свинарева Л.В., Высоцкая О.В. Молекулярногенетические маркеры в диагностике рака желудка. Вестник Российского государственного медицинского университета. 2011; Спецвыпуск1: 342-3. [Byikov 1.1., Mikerova M.S., Svinareva L.V., Vyisotskaya O.V. Molecular genetic markers in the diagnosis of gastric cancer. Vestnik Rossiyskogo gosudarstvennogo meditsinskogo universiteta. 2011; Cpetsvyipusk1: 342-3. (in Russian)]
  19. Бурлев В.А., Бурлев А.В. Экспрессия циклооксигеназ в эутопическом и эктопическом эндометрии у больных с перитонеальной формой эндометриоза. Проблемы репродукции. 2007; 13(2): 45-51. [Burlev V.A., Burlev A.V. Expression of cyclooxygenase in eutopic and ectopic endometrium in patients with peritoneal endometriosis. Problemyi reproduktsii. 2007; 13(2): 45-51. (in Russian)]
  20. Коган Е.А., Сидорова И.С., Низяева Н.В., Демура Т.А., Ежова Л.С., Унанян А.Л. Клинико-морфологические и молекулярно-биологические особенности аденомиоза при сочетании его с аденокарциномой эндометрия. Акушерство и гинекология. 2011; 7-2: 46-50. [Kogan E.A., Sidorova I.S., Nizvaeva N.V., Demura T.A., Eznova L.S., Unanyan A.L. The clinicomorphological and molecular biological characteristics of adenomyosis concurrent with endometrial adenocarcinoma. Akusherstvo i ginekologiya/ Obstetrics and Gynecology. 2011; (7-2): 46-50. (in Russian)]
  21. Ota H., Igarashi S., Sasaki M., Tanaka T. Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomiosis. Hum. Reprod. 2001; 16(3): 561-6.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies