EFFICIENCY OF ALTERNATIVE THERAPY IN PERIMENOPAUSAL AND POSTMENOPAUSAL WOMEN


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Abstract

Objective. To evaluate the efficiency and safety of using the dietary supplement amberen in relieving vasomotor and psychosomatic disorders in perimenopausal and postmenopausal women. Subjects and methods. A randomized double-blind placebo-controlled trial was conducted among 42-60-year-old women with vasomotor and psychosomatic symptoms of menopause. Physical examination and questionnaire survey using Green’s test and Spielberger-Hanin test were done; the plasma levels of gonadotropins, estradiol, leptin, and apolipoproteins were determined. Results. The investigation enrolled 104 women who were randomized into 2 groups. The Green test revealed a statistically significant (p < 0.05) improvement in patients who took amberen in terms of 13 of 21 menopause symptoms. During and after its use, the levels of estradiol, gonadotropins, and leptin were significantly changed, the mean values of weight and waist circumference decreased in the patients. The Spielberger-Hanin test showed that amberen could stabilize the patients’ mental status with significantly reduced anxiety, enhanced resistance to stress, and improved adaptability. Comparative analysis of the measurements of vital signs and blood and urine tests revealed that amberen had a negative effect on the patients. Conclusion. The perimenopausal and postmenopausal use of amberen may be considered to be the method of choice in relieving the symptoms of menopause for women who have contraindications or who do not desire hormone therapy.

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About the authors

Irina V. Kuznetsova

I.M. Sechenov First Moscow State Medical University

MD, Professor, Women’s Health Research Institute, Research Center Moscow, Elanskogo str. 2, bld. 1, Russia

Yulia B. Uspenskaya

I.M. Sechenov First Moscow State Medical University

MD, Women’s Health Research Institute, Research Center Moscow, Elanskogo str. 2, bld. 1, Russia

Natalya I. Borisova

I.M. Sechenov First Moscow State Medical University

PhD, University Clinical Hospital Two Russia, Moscow, B. Pirogovskaya str. 19, bld. 1-3

Elvira V. Zhukova

I.M. Sechenov First Moscow State Medical University

PhD, University Clinical Hospital Two Russia, Moscow, B. Pirogovskaya str. 19, bld. 1-3

Nadezhda G. Berdnikova

I.M. Sechenov First Moscow State Medical University

MD, PhD, Department of Clinical Pharmacology and Internal Propedeutics Russia, Moscow, Yauzskaya str. 11

Yuri K. Gusak

Academician I.P. Pavlov Ryazan State Medical University

MD, Department Ryazan 390026, Vysokovoltnaya str. 9, Russia

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