Search for new markers for preeclampsia


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Abstract

Objective. To def ine the possible role of presepsin (PSP), a new highly sensitive and highly specific marker for systemic inflammatory response and sepsis, in predicting preeclampsia (PE). Subjects and methods. The investigation enrolled 48 women. A study group included patients with hypertensive disorders: preeclampsia (early and late), preeclampsia in the presence of chronic hypertension (CH), and CH. Results. Comparison of PSP levels revealed no significant differences between the groups. What was more, the level of PSP did not correlate with the laboratory parameters of inflammation, which apparently points to the fact that the inflammatory process is inadequately pronounced in the study women. Conclusion. In patients with PE, the systemic inflammatory response has probably other developmental mechanisms unassociated with PSP. There is a need for further investigations searching for the molecular determinants with PE.

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About the authors

Kamilla T. Muminova

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kamika91@mail.ru
clinical intern

Olga V. Vavina

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: olchik0788@mail.ru
a graduate student

Eugeniya S. Polushkina

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: epolushkina@mail.ru
Researcher

Tatiana Yu. Ivanets

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

PhD, Head of Research and Diagnostic Laboratory

Julia V. Bezzubenko

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kamika91@mail.ru
doctor of scientific and diagnostic laboratories

Svetlana O. Strokova

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kamika91@mail.ru
physician of clinical and laboratory diagnostics, laboratory for collection and storage of biomaterials

Roman G. Shmakov

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

MD, chief medical officer

Zulfiya S. Khodzhaeva

Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: zkhodjaeva@mail.ru
MD, Professor, Chief Scientific Officer of 1st obstetric department of pathology of pregnancy

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