ROLE OF THE INHERITED CHARACTERISTICS OF ENERGY METABOLISM IN THE DEVELOPMENT OF PLACENTAL INSUFFICIENCY WITH AN OUTCOME TO INTRAUTERINE GROWTH RESTRICTION


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Abstract

Objective. To provide an update on the relationship between the inherited characteristics of energy metabolism and the development of placental insufficiency with an outcome to intrauterine growth restriction (IUGR). Material and methods. Available literature sources published in the databases Medline, PubMed, and others were sought. 70 sources dealing with the study of a relationship between the gene polymorphisms of energy metabolism and the development of IUGR were found; 35 of them were included in this review. Results. The concepts of the role of mitochondrial DNA, as well as the polymorphisms of nuclear steroid receptors of the peroxisome proliferator-activated receptor (PPAR) family, which are responsible for energy metabolism in the development of IUGR were outlined. The data on a mitochondrial dysfunction biomarker and chronic tissue hypoxia were given. The major subtypes of nuclear steroid receptors of the family PPAR:PPARA-α (alpha), PPAR-δ (delta) or -β (beta), PPARG-γ (gamma) and their importance in the development of the placental complex were also presented. Conclusion. Further studies of inherited risk factors may give a key to understanding the primary cause of IUGR. To identify patients with genetically determined anomalies of cellular metabolism will be able to predict placental insufficiency with an outcome to IUGR during early gestational periods. All will ultimately lead to better perinatal outcomes.

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About the authors

Samat Adylbekovich Azhibekov

Email: samat1901@mail.ru
obstetrician gynecologist, postgraduate student, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia. 620028, Russia, Yekaterinburg, Repina str. 1

Natalia Viktorovna Putilova

Email: putilova-1959@mail.ru
MD, Associate Professor, Head of antenatal protection of the fetus, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia 620028, Russia, Yekaterinburg, Repina str. 1

Tatyana Borisovna Tretyakova

PhD, Senior Researcher, department of biochemical research methods, head of the laboratory of genetics, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia. 620028, Russia, Yekaterinburg, Repina str. 1

Lyudmila Anatolievna Pestryaeva

PhD, head of the clinical-diagnostic department, Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia. 620028, Russia, Yekaterinburg, Repina str. 1

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