ENDOMETRIAL MOLECULAR BIOLOGICAL CHANGES IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS


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Abstract

Objective. To carry out a systematic analysis of the data available in modern literature on molecular changes in the eutopic endometrium of women with external genital endometriosis. Materials and methods. The review included the data of foreign and Russian papers published in 2011-2016 and found in Pubmed on this topic. These papers were the basis for this review; however, for a better understanding of the topic, we expanded searches and included older, but widely quoted articles. Results. This review describes the basic theories of the pathogenesis of endometriosis, which are known at the moment. There is an update on differences in the eutopic endometrium of healthy women and in that of women with endometriosis and endometrioid heterotopias, which include changes in the expression of the factors of adhesion, invasion, angiogenesis, morphogenesis, receptivity, and oncogenesis, as well as hormonal and immune factors. Conclusion. The established differences in the endometrium of healthy women and in that of women with endometriosis and endometrioid heterotopias can not only expand knowledge of the pathogenesis of endometriosis, but also prove to be important therapeutic targets for its treatment. The findings may be also useful in the early diagnosis and prediction of genital endometriosis.

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About the authors

Ekaterina Yuryevna Tikhonchuk

Email: best-kauty@mail.ru
PhD student, Department of Surgical Gynecology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 119997, Russia, Moscow, Ac. Oparina str. 4

Alexandra Vyacheslavovna Asaturova

Email: a_asaturova@oparina4.ru
PhD, senior scientific researcher of pathology department, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 119997, Russia, Moscow, Ac. Oparina str. 4

Leila Vladimirovna Adamyan

Email: l_adamyan@oparina4.ru
MD, professor, academician of RAS; deputy director on science, head of department of operative gynecology, Research Center of Obstetrics, Gynecology and Perinatology; head of department of reproductive medicine and surgery, faculty of postgraduate education, Moscow State University of Medicine and Dentistry 119997, Russia, Moscow, Ac. Oparina str. 4

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