Endometriosis and the development of tumors


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Abstract

Objective. To analyze the data available in the literature on the role of endometriosis in the development and progression of tumors. Material and methods. There is information on the incidence of malignant tumors in women with endometriosis and on the detection rate of the latter in ovarian cancer. Results. The presence of endometriotic foci increases the risk of malignant tumors at various sites, mainly in the ovaries. There are data on the risk of various histological forms of ovarian cancer in patients with endometriosis and the latter is shown to cause clear-cell and endometrioid carcinomas. The major pathways for malignant transformation of endometriotic foci are noted to be genomic disorders, gene mutations, and changes in the expression of growth factors, as well as impaired cell proliferation and apoptosis. Conclusion. Most investigators support the concept of the pro-oncogenic effect of endometriosis.

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About the authors

Alexander Ivanovich Shchegolev

Email: ashegolev@oparina4.ru
doctor of medical science, professor, head of department for pathological anatomy, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Anatoliy Gennadievich Bykov

Email: a_bykov@oparina4.ru
graduate student of department of operative gynecology Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Uliana Nikolaevna Tumanova

Junior Researcher, Pathology Department, Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Stanislav V. Pavlovich

Email: s_pavlovich@oparina4.ru
MD, PhD, Scientific secretary, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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