THE SPECIFIC FEATURES OF ENDOGLYCOSIDASE EXPRESSION IN THE FOCI OF ADENOMYOSIS IN REPRODUCTIVE-AGED PATIENTS WITH MYOMA OF THE CORPUS UTERI


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Abstract

Objective. To study the pattern of expression of heparanase-1 (HPSE-1) and its substrate heparan sulfate (HSP) in the eutopic and heterotopic endometrium of reproductive-aged women with adenomyosis and leiomyomatosis in relation to the volume of the corpus uteri. Subjects and methods. An immunohistochemical study of the expression of HPSE-1 and HSP in the intraoperative specimens obtained from 48patients was performed. Results. If the volume of the corpus uteri was less or more than 12 weeks, the eutopic endometrium during the proliferative phase of the cycle showed a minimal HPSE expression level in single stromal cells. In the foci of adenomyosis, HPSE-1 was expressed in the epithelium and subepithelial microvessels, negatively correlating with the expression of HSP; in the patients with a uterine corpus volume of more than 12 weeks, the expression of HPSE-1 was much higher than in the patients with that of less than 12 weeks (p < 0.001). Conclusion. Enhanced HPSE-1 activity in the heterotopic endometrium was combined with progressive leimyomatosis and may facilitate endometrial invasion into the myometrium to develop adenomyosis.

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About the authors

Igor O. Marinkin

Email: rector@ngmu.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology, Rector of the Novosibirsk State Medical University, Ministry of Health of Russia 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Lyudmila Anatol'evna Piven

Email: ludmilapiv@yandex.ru
PhD, Associate Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Dmitry A. Solyanikov

Assistant of the Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Yulia S. Timofeeva

Email: julie_srg@mail.ru
registrar of the Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Vitaly M. Kuleshov

Email: kuleshov_vm@mail.ru
MD, Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Tatyana Mikhaylovna Sokolova

Email: tatyana3965@mail.ru
MD, Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Konstantin Yurevich Makarov

Email: fdpngma@mail.ru
MD, Associate Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Vladimir V. Omigov

Email: omigov@vector.nsc.ru
PhD, Scientific Laboratory of cell biology and fundamentals of the reproduction of the Central Research Laboratory, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

Svetlana V. Aidagulova

Email: a_sv@ngs.ru
Sc.D., Professor, Head of the Laboratory of cell biology and fundamentals of the reproduction of the Central Research Laboratory, Novosibirsk State Medical University, Ministry of Health of Russia. 630091, Russia, Novosibirsk, Krasny Prospekt, 52

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