THE IMITATORS OF SEVERE PREECLAMPSIA AND HELLP SYNDROME: DIFFERENT TYPES OF PREGNANCY-ASSOCIATED THROMBOTIC MICROANGIOPATHY


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on states that can imitate preeclampsia, in the genesis of which pregnancy will play not a major role, but a trigger one. Material and methods. The review included the data of foreign and Russian papers published in the past 5 years and found in Pubmed on this topic. Results. The paper describes a differential diagnostic search between the different types of thrombotic microangiopathy (TMA), which can be induced by pregnancy since a correct diagnosis frequently affects life expectancy primarily in a mother and her child. Thrombotic thrombocytopenic purpura and atypical hemolytic-uremic syndrome are life-threatening conditions during pregnancy and require timely adequate treatment and further follow-up. HELLP-syndrome and preeclampsia have similar clinical characteristics. Conclusion. The main differences between preeclampsia and HELLP syndrome, on the one hand, and life-threatening conditions, such as atypical hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura, and catastrophic antiphospholipid syndrome, on the other hand, are considered. An algorithm of diagnostic search for pregnancy-associated TMA is proposed, key differences determined, and therapeutic approaches approached.

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About the authors

Tatyana Valeryevna Kirsanova

Email: A_Tatya@mail.ru
PhD, senior researcher of the Department of Reproductive Hematology and Clinical Hemostasis, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Maria Alekseevna Vinogradova

Email: mary-grape@ya.ru
PhD, head of Department of Reproductive Hematology and Clinical Hemostasis, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

Tatyana Anatolyevna Fedorova

Email: tfedorova1@mail.ru
Professor, MD, the Chief of Department of Transfusiology and Extracorporeal Haemocorrection, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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