Recurrent miscarriage: What depends on a male partner?


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the role of a man in recurrent miscarriage (RM) and reproductive losses in his spouse. Material and methods. The review included data of foreign and Russian papers on this topic which were published in the last 10 years and found in Pubmed database. Results. The paper describes the negative impact of higher sperm DNA fragmentation on the course of pregnancy, especially in its f irst trimester, on the occurrence of RM or non-developing pregnancy, and on the effectiveness of assisted reproductive technology (ART) programs. It considers the etiology and pathogenesis of sperm DNA damage. The positive impact of modifying unhealthy lifestyle factors, the role of varicocelectomy and antioxidant therapy, and recent advances in ART are presented. There is evidence that various disorders (translocations) of normal male karyotype are implicated in pathogenesis of pregnancy loss. The paper considers the role of urological surgery and preimplantation genetic diagnosis in solving this problem. Conclusion. There is a need for further investigations to evaluate the impact of a male partner on pregnancy losses, ART outcomes and healthy birth rates. New ways are proposed to solve the problems of RM in a couple, by correcting abnormalities in men via sperm DNA fragmentation reduction.

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About the authors

Ruslan I. Ovchinnikov

Email: r_ovchinnikov@oparina4.ru
MD, PhD, Head of the Department of Andrology and Urology Clinic, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Safa I. Khamidov

Email: s_gamidov@oparina4.ru
prof., Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; the head of Department of Andrology and Urology, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

Alina Yu. Popova

Email: a_popova@oparina4.ru
PhD, associate professor, Department of Obstetrics, Gynecology, Perinatology and Reproductology, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; senior researcher o of the Department of Andrology and Urology Clinic, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia 117997, Russia, Moscow, Ac. Oparina str. 4

I. V Ushakova

Email: ir_ushakova@oparina4.ru
Ph.D., embryologist, department of reproductive, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

O. N Golubeva

Email: on_golubeva@oparina4.ru
PhD, embryologist, department of reproductive, Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia. 117997, Russia, Moscow, Ac. Oparina str. 4

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